Academic Staff > Y.C. Wong

 

Y.C. Wong ( 王雲川 )
Professor
B.Sc., M.Sc., Ph.D.

Department of Anatomy
1/F. Laboratory Block
Faculty of Medicine Building
21 Sassoon Road, Hong Kong

Anatomy Office: (852) 2819-9226 (voice)
Anatomy Office: (852) 2817-0857 (fax)

E-mail: ycwong@hkucc.hku.hk

Jump to: Background / Research / Publications

Background

Education
B.Sc.(Zool) Nanyang Univ. Singapore; M.Sc.; Ph.D. Univ. Western Ontario, Canada.CBiol; MIBiol.

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Research

My main area of research is on hormonal carcinogenesis especially in prostate and breast cancer with special reference to the importance of epithelial-stroma interactions and factors regulating the development and progression of cancers.

The main foci of research are in the following areas:

1. The role of Id1 gene in prostate carcinogenesis.
2. Specific protein markers for human benign prostatic hyperplasia (BPH).
3. Id1 gene and development of prostate cancer from androgen dependent to androgen independent cancer.
4. Id1 gene as an oncogene in prostate cancer initiation.

Research Funding (external): (last 5 years)

1. The role of Id-1 gene in prostate carcinogenesis and its relationship to invasiveness of prostate cancer. As PI.
CERG-RGC: $699,600. 2001

2. The Beijing, Hong Kong and UK collaborative study on the molecular genetic basis of differential susceptibility of prostate cancer between Chinese and Caucasian. As PI. (Co-Is In Hong Kong, Dr. XH Wang; In Peking University, Prof YQ Na and DQ Xin; In U of Liverpool, Prof Chris Foster and Dr. YQ Ke).
HKU Foundation Seed Funding: $810,000. 2003

3. The Id-1 activation of NF-κB and its role in development of androgen-independent prostate cancer. As PI.
CERG-RGC: $2,070,000. 2003

4. Identification and evaluation of specific marker proteins from secretions of benign prostatic hyperplasia (BPH). As PI. (Co-Is: Hong Kong, Dr. XH Wang; Beijing: Institute of Urology, Peking University, Prof YQ Na, DQ Xin; Peoples’ Hospital, Dr. KX Xu).
NSFC-RGC: $610,600. 2003

5. The role of Id1 gene in initiation of prostate carcinogenesis. As PI.
CERG-RGC: $1,857,250. 2004. (Co-I, Dr. XH Wang)

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Selected Publications

  1. YZ Wang and YC Wong (1998). Sex hormone-induced prostatic carcinogenesis in the Noble rat: The role of insulin-like growth factor-1 (IGF-1) and vascular endothelial growth factor (VEGF) in the development of prostate cancer. Prostate 35:165-177.

  2. W Xie, YC Wong, SW Tsao and NS Wong (2000). Expression of a kallikrein-like protein in prostatic intraepithelial neoplasia in ventral prostate of the Noble rat. Prostate 42:8-17.

  3. W Xie, SW Tsao and YC Wong (2000). Correlation of increased apoptosis and proliferation with development of prostatic intraepithelial neoplasia (PIN) in ventral prostate of the Noble rat. Prostate 44:31-39.

  4. YC Wong and YZ Wong (2000). Growth factors and epithelial-stromal interactions in prostate cancer development. International Review of Cytology 199: 65-116.

  5. NNC Tam, SSM Chung, Davy TW Lee and YC Wong (2000). Aberrant expression of hepatocyte growth factor and its receptor, c-met, during the sex hormone-induced prostatic carcinogenesis in the Noble rat. Carcinogenesis 21:2183-2191.

  6. YC Wong, W Xie and SW Tsao (2000). Structural changes and alteration in expression of TGFb 1 and its receptors in prostatic intraepithelial neoplasia (PIN) in ventral prostate of the Noble rat. Prostate 45:289-298.

  7. XS Ouyang, XH Wang, DTW Lee, SW Tsao and YC Wong (2001). Upregulation of ID-1, TRPM-2 and MMP-7 during sex hormone-induced prostate carcinogenesis in the Noble rat. Carcinogenesis. 22:965-73.

  8. XS Ouyang, XH Wang, DTW Lee, SW Tsao and YC Wong (2002). Overexpression of Id-1 in prostate cancer. J Urol. 167:2598-2602.

  9. NNC Tam, SSM Chung, SW Tsao, and YC Wong (2002). De-differentiation of stromal smooth muscle and prostate carcinogenesis. Differentiation. 70:633-645.

  10. XS Ouyang, XH Wang, SW Tsao and YC Wong (2002). Id-1 stimulates serum independent prostate cancer cell proliferation through inactivation of p16INK4a/pRb pathway. Carcinogenesis 23:721-725.

  11. PMT Ling, XH Wang, SW Tsao and YC Wong (2002). Down-regulation of Id-1 expression is associated with TGF-b 1-induced growth arrest in prostate epithelial cells. Biochemica and Biophysica Acta. 1570:145-152.

  12. MT Ling, XH Wang, XS Ouyang, KW Lee, KX Xu, TY Fan, SW Tsao and YC Wong (2002). Activation of MAPK signaling pathway is essential for Id-1 induced serum independent prostate cancer cell growth. Oncogene 21: 8498-8505.

  13. MT Ling, XH Wang, XS Ouyang, KX Xu, SW Tsao and YC Wong (2003). Id-1 expression promotes cell survival through activation of NF-kB signaling pathway in prostate cancer cells. Oncogene 22: 4498-4508.

  14. KX Xu, XH Wang, MT Ling, DTW Lee, TY Fan, FL Chan, JJW Xuan, SW Tsao and YC Wong (2002). Identification and characterization of an isoform of PSP94 protein in benign prostatic hyperplasia (BPH). Electrophoresis 24:1311-1318.

  15. TKW Lee, K Man, MT Ling, X Wang, YC Wong, CM Lo, RT Poon, IO Ng and S Fan (2003). Over-expression of Id-1 induces cell proliferation through inactivation of p16INK4a/RB pathway in hepatocellular carcinoma. Carcinogenesis 24:1729-1736.

  16. YC Wong, XH Wang and MT Ling (2003). Prostate development and carcinogenesis. International Review of Cytology. 227:65-130.

  17. XH Wang, SW Tsao, YC Wong and ALM Cheung (2003). Induction of senescent-like growth arrest as a new target in anticancer treatment.  Current Cancer Drug Targets 3:153-160.

  18. J Kwong, PSF Chan, K Lui, JW Xuan, SM Ho, YC Wong and Franky L Chan (2003). Expression study of three secretary proteins (prostatic secretary protein of 94 amino acids, probasin and seminal vesicle secretion II) in dysplastic and neoplastic rat prostates. Prostate. 56:81-97.

  19. HX Si, SW Tsao, CSP Poon, LD Wang, YC Wong and ALM Cheung (2003). Viral load of human papillomavirus (HPV) in esophageal squamous cell carcinoma. International J Cancer. 103:496-500.

  20. XH Wang, DY Jin, HL Wong, H Feng, YC Wong and SW Tsao (2003). MAD2-induced sensitization to vincristine is associated with mitotic arrest and Raf/Bcl-2 phosphorylation in nasopharyngeal carcinoma cells. Oncogene 22:109-116.

  21. A Thota, M Karajgika, W Duan, MY Gabril, FL Chan, YC Wong, H Sakai, JL Chin, M Moussa and JW Xuan (2003). Mouse PSP94 expression is prostate tissue-specific as demonstrated by a comparison of multiple antibodies against recombinant proteins. J Cell. Biochem. 88:999-1011.

  22. X. Wang, M T Ling, XY Guan, S W Tsao, HW Cheung, DT Lee and YC Wong (2004). Identification of a novel function of TWIST, a bHLH protein, in the development of acquired taxol resistance in human cancer cells. Oncogene 23:474-482.

  23. YC Wong, MT Ling, XH Wang, XS Ouyang, ALM Cheung and Franky L Chan (2005). Id-1 protein as a new marker of prostate cancer. Hormonal Carcinogenesis IV. Edited by JJ Li, Sara A Li and Antonio Llombart-Bosch, Springer Science Inc. 2005. 197-207.

  24. MT Ling, XH Wang, Davy T Lee, PC Tam, SW Tsao and YC Wong (2004). Id-1 expression induces androgen independent prostate cancer cell growth through activation of EGF-R. Carcinogenesis. 25:517-525.

  25. HW Cheung, MT Ling, SW Tsao, YC Wong and XH Wang (2004). Id-1-induced Raf/MEK pathway activation is essential for its protective role against apoptosis in nasopharyngeal carcinoma cells. Carcinogenesis 25:881-887.

    HM Li, ZH Zhuang, Q Wang, XH Wang, HL Wong, HC Feng, DY Jin, MT ling, YC Wong, AG Eliopoulos, LS Young, DP Huang and SW Tsao (2004). Epstein-Barr virus latent membrane protein-1 (LMP1) up-regulates Id1 expression in nasopharyngeal epithelial cells. Oncogene. 23:4488-4494.

  26. YC Wong, XH Wang and MT Ling (2004). Id1 expression and cell survival. A mini-review. Apoptosis. 9:279-289.

  27. XH Wang and YC Wong (2004). Induction of tumour cell senescence: a new strategy in anticancer treatment. Medicinal Chemistry Reviews Online 1:369-379.

  28. Q Wang, SW Tsao, SB Fu, WC Xue, XN Meng, HC Feng, YC Wong and XH Wang (2004). Overexpression of Id1 in gastric adenocarcinoma: Implication for a novel diagnostic marker. Anticancer Res. 24: 881-886.

  29. YeeLeng Yap, XueWu Zhang, MT Ling, XiangHong Wang, YC Wong, Antoine Danchin (2004). Classification between tumor and normal tissues based on the pair-wise gene expression ratio. BMC Cancer 4:72 (1-17).

  30. HW Cheung, DY Jin, MT Ling, YC Wong, SW Tsao and XHWang (2005). MAD2 expression induces chemosensitization to a DNA damaging agent, cisplatin, in nasopharyngeal carcinoma cells. Cancer Research. 65(4):1450-1458.

  31. X Wang, YC Wong and DY Jin. (2005). Mitotic checkpoint: a therapeutic target in the treatment of human cancer. Letters in Drug Design and Discovery 2:97-104.

  32. HW Cheung, YP Ching, JM. Nicholls, MT Ling, YC Wong, N Hui, A Cheung, S W Tsao, Q Wang, DY Jin and X Wang (2005). Epigenetic inactivation of CHFR in nasopharyngeal carcinoma through promoter methylation. Mol. Carcinogenesis 43:237-245.

  33. XM Zhang, MT Ling, HC Feng, YC Wong, SW Tsao and X Wang (2004). Id-1 stimulates cell proliferation through activation of EGF-R in ovarian cancer cells. Br J Cancer 91: 2042-2047

  34. MT Ling, Tracy CM Lau, C Zhou, CW Chua, WK Kwok, Q Wang, X Wang and YC Wong (2005). Overexpression of Id-1 in prostate cancer cells promotes angiogenesis, through the activation of vascular endothelial growth factor (VEGF). Carcinogenesis, 2005, 26(10), 1668-1676.

  35. C Zhou, MT Ling, TW Lee, K Man, X Wang and YC Wong (2006). FTY720, a fungus metabolite, inhibits invasion ability of androgen-independend prostate cancer cells through inactivation of RhoA-GTPase. Cancer Letters, Volume 233, Issue 1, Pages 36-47

  36. HX Si, SW Tsao, CSP Poon, YC Wong and ALM Cheung (2005). Physical status of HPV-16 in esophageal squamous cell carcinoma. J Clin Virol. 32:19-23.

  37. CM Hui, PY Cehung, MT Ling, SW Tsao XH Wang, YC Wong and ALM Cheung (2006). Id1 promotes proliferation of p53-deficient esophageal cancer cells. Inter J Cancer. 2006 Feb 27;119(3):508-514 [Epub ahead of print]

  38. TK Lee, K Man, JW Ho, CK Sun, KT Ng, XH Wang, YC Wong, IOL Ng, RR Xu and ST Fan (2004). FTY720 induces apoptosis of human hepatoma cell lines through PI3-K-mediated Akt dephosphorylation. Carcinogenesis 25:2397-2405.

  39. CW Chua, DTW Lee, MT Ling, C Zhou, K Man, J Ho, Franky L Chan, X Wang and YC Wong (2005). FTY720, a fungus metabolite, inhibits in vivo growth of androgen independent prostate cancer. International Journal of Cancer. 117:1039-1048.

  40. XM Zhang, XH Wang, MT Ling, YC Wong (2006)  Inactivation of Id-1 in prostate cancer cells: A potential therapeutic target in inducing chemosensitization to taxol through activation of JNK pathway. International J Cancer. 118:2072-2081.

  41. WK Kwok, MT Ling, TW Lee, TCM Lau, Rita C Zhou, XM Zhang, CW Chua, KW Chan, Franky L Chan, Carlotta Glackin, YC Wong and X Wang (2005). Upregulation of Twist in prostate cancer and its implication as a therapeutic target. Cancer Research 65:5153-5162.

  42. MT Ling, WK Kwok, Maggie K Fung, XH Wang, and YC Wong (2006). Proteosome mediated degradation of Id-1 is associated with TNFα-induced apoptosis in prostate cancer cells. Carcinogenesis 27:205-215.

  43. Q Wang, S W Tsao, John M. Nicholls, Tadamasa Ooka, HW Cheung, Songbin Fu, Y.C. Wong and Xianghong Wang (2006). Anti-apoptotic role of Barf1 in gastric cancer cells. Cancer Letters. 2005 Jul 26; [Epub ahead of print].

  44. HL Wong, XH Wang, RCC Chang, HC Feng, Q Wang, KW Lo, DP Huang, PW Yuen, K Takda, YC Wong and SW Tsao (2005). Stable expression of EBERs in immortalized nasopharyngeal epithelial cells confers resistance to apoptotic stress. Molecular Carcinogenesis 44:92-101.

  45. QJ Chu, MT Ling, HW Cheung, G Wang, SW Tsao, XH Wang and YC Wong (2006). A novel anticancer effect of garlic derivatives: inhibition of cancer cell invasion through restoration of E-cadherin expression. Carcinogenesis. 2006 May 4; [Epub ahead of print]

  46. MT Yuen, LK Leung, J Wang, YC Wong and Franky L Chan (2005) Enhanced induction of prostatic dysplasia and carcinoma in Noble rat model by combination of neonatal estrogen exposure and hormonal treatments at adulthood. International Journal of Oncology 27:1685-1695.

  47. M. T. Ling, T.C.M. Lau, C. Zhou, K.W. Kwok, Q. J. Chu, X.H. Wang, and Y.C. Wong. (2005). Id-1 gene and prostate cancer angiogenesis. Proceeding of 4th Asia-Pacific IAP Congress, Beijing, China. August 22-26, 2005.  83-91

  48. HW Cheung, AC Chun, Q Wang, W Deng, L Hu, XY Guan, JM Nicholls, MT Ling, YC Wong, SW Tsao, DY Jin and XH Wang (2006). Inactivation of human MAD2B in nasopharyngeal carcinoma cells leads to chemosensitization to DNA damaging agents. Cancer Research. In Press.

  49. Yi Ding, Gang Wang, Ming Tat Ling, Y.C. Wong, Xin Li, Yanqun Na, Xiaomeng Zhang, Chee Wai Chua,  Xianghong Wang and Dianqi Xin (2006) Significance of Id-1 upregulation and its association with EGFR in bladder cancer cell invasion. International J Oncology.28(4): 847-854.

  50. Kexin Xu, Ming-tat Ling, Xianghong Wang and YC Wong (2006). Evidence of a novel biomarker, as1-Casein, a milk protein, in benign prostatic hyperplasia. Prostate Cancer and Prostatic Diseases. 2006 May 9; [Epub ahead of print]

  51. KJ Di, MT Ling, SW Tsao, YC Wong and XH Wang (2006). Sensitization effect of Id-1 inactivation on TGF-β1-induced growth arrest in prostate epithelial cells. Biology of the Cell.  In Press.

  52. MT Ling, XH Wang and YC Wong (2006). Multiple role of Id-1 in cancer progression. Invited Mini-review. Differentiation. In Press.

  53. Hiu-Fung Yuen, Chee-Wai Chua, Yuen-Piu Chan, YC Wong, Xianghong Wang, and Kwok-Wah Chan (2006). Id proteins expression in prostate cancer: high level expression of Id-4 in primary prostate cancer is associated with development of metastases. Modern Pathology, 2006 Mar 31; [Epub ahead of print]

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