Academic Staff > W. Wu
Wutian Wu ( 吳武田 )
M.Med. (Sun Yat Sen), Ph.D. (Old Dominion)
Department of Anatomy
L1-51, Laboratory Block
Faculty of Medicine Building
21 Sassoon Road, Hong Kong
Anatomy Office: (852) 3917-9187 (voice)
Anatomy Office: (852) 2817-0857 (fax)
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Education / Training
MB.BS., Sun Yat-Sen University of Medical Sciences,
Guangzhou, The People’s Republic of China (M.D.
equivalent, 1976) (1972-1976)
M.S., Sun Yat-Sen University of Medical Sciences, Graduate
School, Guangzhou, The People’s Republic of China (1981)
PhD, Graduate School of Old Dominion University and Eastern
Virginia Medical School, Norfolk, Virginia, USA (1991)
Postdoctoral Fellow in Dr. R.J. Reiter’s lab, Department of
Cellular and Structural Biology. UTHSC at San Antonio,
Texas, USA (1986-1987)
Research Fellow in Dr. D. E. Scott’s lab, Department of
Anatomy & Neurobiology, Eastern Virginia Medical School,
Norfolk, Virginia, USA (1987-1988)
Research Fellow, Department of Plastic Surgery. Eastern
Virginia Medical School. Norfolk, Virginia, USA (1991-1992)
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Neuronal injury and regeneration in CNS and PNS
Spinal cord injury
Neuronal degenerative diseases
My research focus on the following aspects: to
understand mechanisms underlying neuronal death and
regeneration after axonal injury; to explore therapeutic
approached for neuronal injury and neurodegenerative
diseases such spinal cord injury, peripheral nerve
injury, stroke, multiple sclerosis and Alzheimer’s
disease. Currently, we have been using microsurgical
approach, stem cell transplantation, small molecules and
trophic factors, antibodies and inhibitory molecules,
nanomatrieals and components from Chinese medicine for
the treatment of neuronal injury.
Role of glial cells in neural injury and regeneration.
Principal Investigator. China “973” project
(Grant number: 2011CB504402), RMB5,320,000.
Spinal cord injury research. Principal Investigator.
HK$250,000, Government matching fund, 2011-
Use of human induced pluripotent stem cells (iPSCs) from
mesenchymal cells of the umbilical cord (UMCs) for
motoneuron degeneration. Principal Investigator.
HK$250,000. Seed fund from LKS Faculty of Medicine.
Bridge the gap in nerve tissue injury to promote axonal
regeneration with self-assembling peptide nanofibre scaffold
(SAPNS). Principal Investigator. HK$67,000.
Seed fund from the University of Hong Kong. 2011-
Fund from State Key Lab of HKU, Principal Investigator.
Influence of corticospinal tract on the survival and
regeneration of spinal motor neurons after axonal injury.
Principal Investigator. HKU, HK$95,500. 2012-
Treatment of lumbosacral spinal cord injury by using
neurotization and transplantation of motoneurons derived
from induced Neural Stem Cells (iNSC) and Muse cells.
HK$2,000,000. Principal Investigator. HK SCI
Awards and Honors
Research output prize, The University of Hong Kong, Hong
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Mi S, Hu B, Hahm K, Luo
Y, Hui SK, Yuan Q, Wong WM, Wang L, Su HX, Chu
TH, Guo JS, Zhang WM, So KF, Pepinsky B, Shao ZH, Graff C,
Garber E, Jung V, Wu XK, Wu W*: LINGO-1 Antagonist
Promotes Spinal Cord Remyelination and Axonal Integrity in
Experimental Autoimmune Encephalomyelitis. Nature Medicine,
13:1228-1233, 2007. (Cover Image)
Guo JS, Su HX, Zeng YS, Liang YX, Ellis-Behnke RG, So KF and
Wu W*: Reknitting the spinal cord using a
self-assembling peptide nanofiber scaffold to promote
functional recovery. Nanomed-Nanotechnol, 3:311-321, 2007.
Chu TH, Du Y and Wu W*:
Motor nerve graft is better than sensory nerve graft for
survival and regeneration of motoneurons after spinal root
avulsion in adult rats.
Exp. Neurol. 212:562-565, 2008.
Su HX, Zhang WM, Guo JS, Guo AC, Yuan QJ, Wu W*.
Lithium enhances the neuronal differentiation of neural stem
cells in vitro and after transplantation into the avulsed
ventral horn of adult rats through the secretion of
brain-derived neurotrophic factor. J. Neurochemistry.
Yuan QJ, Hu B, Wu Y, Chu TH, Su HX, Zhang WM, So KF, Lin ZL
and Wu W*: Induction of c-Jun phosphorylation in
spinal motoneurons in neonatal and adult rats following
axonal injury. Brain Res, 1320:7-15, 2010.
Zhang W, Qing Y, Zeng YS, Zhang XB, Yi X, Wang JM, Chen SJ,
Yan Y, Bruce IC and Wu W*: Implantation of
Adult Bone Marrow-Derived Mesenchymal Stem Cells Transfected
with the Neurotrophin-3 Gene and Pretreated with Retinoic
Acid in Completely Transected Spinal Cord. Brain Res.
Su HX, Wu Y, Yuan QJ, Guo JS, Zhang WM and Wu W*:
Optimal time point for neuronal generation of transplanted
neural progenitor cells in injured spinal cord following
root avulsion. Cell Transplantation. 20:167-176, 2011.
Chu TH, Wang L, Guo AC, Chan WK, Wong WM, Wu W*:
GDNF-treated acellular nerve graft promotes motoneuron axon
regeneration after implantation into the avulsed spinal
cord. Neuropathology and Applied Neurobiology, 38, 681-695.
Su HX, Wang LH, Cai JL, Yuan QJ, Yang XY, Sang YH, Wong WM,
Huang WH, Li ZY, Wang YT, Pei DQ, So KF, Qin DJ,
Wu W: Transplanted motoneurons derived from human
induced pluripotent stem cells form functional connections
with target muscle. Stem Cells Research, 11:529-539, 2013.
Zhan XD, Gao MY, Jiang YW, Zhang WW, Wong WM, Yuan QJ, Su HX,
Kang XN, Dai X, Zhang WY, Guo JS*, Wu W*, Nanofiber
scaffolds facilitate functional regeneration of peripheral
nerve injury, Nanomedicine 9:305-315, 2013. Selected as
cover story and feature article.
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