Academic Staff > W. Wu

 

Wutian Wu ( 吳武田 )
Professor
B.Med.,  M.Med. (Sun Yat Sen),  Ph.D. (Old Dominion)

Department of Anatomy
L1-51, Laboratory Block
Faculty of Medicine Building
21 Sassoon Road, Hong Kong

Anatomy Office: (852) 2819-9187 (voice)
Anatomy Office: (852) 2817-0857 (fax)

E-mail: wtwu@hku.hk

Jump to: Background / Research / Publications

Background

Education / Training

  • MB.BS., Sun Yat-Sen University of Medical Sciences, Guangzhou, The People’s Republic of China (M.D. equivalent, 1976) (1972-1976)

  • M.S., Sun Yat-Sen University of Medical Sciences, Graduate School, Guangzhou, The People’s Republic of China (1981) (1979-1982)

  • PhD, Graduate School of Old Dominion University and Eastern Virginia Medical School, Norfolk, Virginia, USA (1991) (1988-1991)

  • Postdoctoral Fellow in Dr. R.J. Reiter’s lab, Department of Cellular and Structural Biology.  UTHSC at San Antonio, Texas, USA (1986-1987)

  • Research Fellow in Dr. D. E. Scott’s lab, Department of Anatomy & Neurobiology, Eastern Virginia Medical School, Norfolk, Virginia, USA (1987-1988)

  • Research Fellow, Department of Plastic Surgery.  Eastern Virginia Medical School. Norfolk, Virginia, USA (1991-1992)

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Research

Research Interests

  • Neuronal injury and regeneration in CNS and PNS          

  • Spinal cord injury

  • Neuronal degenerative diseases

  • Stem cells

  • Nanomaterials

Research Description

My research focus on the following aspects: to understand mechanisms underlying neuronal death and regeneration after axonal injury; to explore therapeutic approached for neuronal injury and neurodegenerative diseases such spinal cord injury, peripheral nerve injury, stroke, multiple sclerosis and Alzheimer’s disease. Currently, we have been using microsurgical approach, stem cell transplantation, small molecules and trophic factors, antibodies and inhibitory molecules, nanomatrieals and components from Chinese medicine for the treatment of neuronal injury.

Research Grants

  • Role of glial cells in neural injury and regeneration. Principal Investigator. China “973” project (Grant number: 2011CB504402), RMB5,320,000.  2011-2015.

  • Spinal cord injury research. Principal Investigator. HK$250,000, Government matching fund, 2011-

  • Use of human induced pluripotent stem cells (iPSCs) from mesenchymal cells of the umbilical cord (UMCs) for motoneuron degeneration. Principal Investigator. HK$250,000. Seed fund from LKS Faculty of Medicine. 2011-

  • Bridge the gap in nerve tissue injury to promote axonal regeneration with self-assembling peptide nanofibre scaffold (SAPNS). Principal Investigator. HK$67,000. Seed fund from the University of Hong Kong. 2011-

  • Fund from State Key Lab of HKU, Principal Investigator. HK$350,000. 2011-

  • Influence of corticospinal tract on the survival and regeneration of spinal motor neurons after axonal injury. Principal Investigator. HKU, HK$95,500. 2012-

  • Treatment of lumbosacral spinal cord injury by using neurotization and transplantation of motoneurons derived from induced Neural Stem Cells (iNSC) and Muse cells. HK$2,000,000. Principal Investigator. HK SCI Fund. 2012-

Awards and Honors

  • Research output prize, The University of Hong Kong, Hong Kong (2008)

  • 国家科学技术进步奖二等奖 (2012)

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Selected Publications

  1. Mi S, Hu B, Hahm K, Luo Y, Hui SK, Yuan Q, Wong WM, Wang L, Su HX, Chu TH, Guo JS, Zhang WM, So KF, Pepinsky B, Shao ZH, Graff C, Garber E, Jung V, Wu XK,  Wu W*: LINGO-1 Antagonist Promotes Spinal Cord Remyelination and Axonal Integrity in MOG-Induced Experimental Autoimmune Encephalomyelitis. Nature Medicine, 13:1228-1233, 2007. (Cover Image)
     

  2. Guo JS, Su HX, Zeng YS, Liang YX, Ellis-Behnke RG, So KF and Wu W*: Reknitting the spinal cord using a self-assembling peptide nanofiber scaffold to promote functional recovery. Nanomed-Nanotechnol, 3:311-321, 2007.
     

  3. Chu TH, Du Y and Wu W*: Motor nerve graft is better than sensory nerve graft for survival and regeneration of motoneurons after spinal root avulsion in adult rats. Exp. Neurol. 212:562-565, 2008.
     

  4. Su HX, Zhang WM, Guo JS, Guo AC, Yuan QJ, Wu W*. Lithium enhances the neuronal differentiation of neural stem cells in vitro and after transplantation into the avulsed ventral horn of adult rats through the secretion of brain-derived neurotrophic factor. J. Neurochemistry. 108:1385-1398, 2009.
     

  5. Yuan QJ, Hu B, Wu Y, Chu TH, Su HX, Zhang WM, So KF, Lin ZL and Wu W*: Induction of c-Jun phosphorylation in spinal motoneurons in neonatal and adult rats following axonal injury. Brain Res, 1320:7-15, 2010.
     

  6. Zhang W, Qing Y, Zeng YS,  Zhang XB, Yi X,  Wang JM, Chen SJ, Yan  Y, Bruce IC and Wu W*: Implantation of Adult Bone Marrow-Derived Mesenchymal Stem Cells Transfected with the Neurotrophin-3 Gene and Pretreated with Retinoic Acid in Completely Transected Spinal Cord. Brain Res. 1357:256-267, 2010.
     

  7. Su HX, Wu Y, Yuan QJ, Guo JS, Zhang WM and Wu W*: Optimal time point for neuronal generation of transplanted neural progenitor cells in injured spinal cord following root avulsion. Cell Transplantation. 20:167-176, 2011.
     

  8. Chu TH, Wang L, Guo AC, Chan WK, Wong WM, Wu W*: GDNF-treated acellular nerve graft promotes motoneuron axon regeneration after implantation into the avulsed spinal cord. Neuropathology and Applied Neurobiology, 38, 681-695. 2012.
     

  9. Su HX, Wang LH, Cai JL, Yuan QJ, Yang XY, Sang YH, Wong WM, Huang WH, Li ZY, Wang YT, Pei DQ, So KF, Qin DJ, Wu W: Transplanted motoneurons derived from human induced pluripotent stem cells form functional connections with target muscle. Stem Cells Research, 11:529-539, 2013.
     

  10. Zhan XD, Gao MY, Jiang YW, Zhang WW, Wong WM, Yuan QJ, Su HX, Kang XN, Dai X, Zhang WY, Guo JS*, Wu W*, Nanofiber scaffolds facilitate functional regeneration of peripheral nerve injury, Nanomedicine 9:305-315, 2013. Selected as cover story and feature article.

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