Sookja K. Chung ( 金淑子 )
Professor
B.A. (Lewis), M.A. Ph.D. (Ill.)

Department of Anatomy
1/F. Laboratory Block
Faculty of Medicine Building
21 Sassoon Road, Hong Kong

Anatomy Office: (852) 2819-9172 (voice)
Anatomy Office: (852) 2817-0857 (fax)

E-mail: skchung@hkucc.hku.hk

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Research

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Selected Publications

Publication during 2008 to 2009

1. Tang WH, Wu S, Wong TM, Chung SK, Chung SS: Polyol pathway mediates iron-induced oxidative injury in ischemic-reperfused rat heart. Free Radic Biol Med. 2008 May 15. [Epub ahead of print]

2. Qiu L, Wu X, Chau JF, Szeto IY, Tam WY, Guo Z, Chung SK, Oates PJ,Chung SS, Yang JY: Aldose reductase regulates hepatic peroxisome proliferator-activated receptor alpha phosphorylation and activity to impact lipid homeostasis. J Biol Chem. 2008 Jun 20;283(25):17175-83. Epub 2008 Apr 29.

3. Chan AW, Ho YS, Chung SK, Chung SS. Synergistic effect of osmotic and oxidative stress in slow-developing cataract formation. Exp Eye Res. 2008 Nov;87(5):454-61. Epub 2008 Aug 9.

4. Chan KC, Cai KX, Su HX, Hung VK, Cheung MM, Chiu CT, Guo H, Jian Y, Chung SK, Wu WT, Wu EX, Early detection of neurodegeneration in brain ischemia by manganese-enhanced MRI. Conf Proc IEEE Eng Med Biol Soc. 2008:3884-7, 2008

5. Leung JW, Chung SS, Chung SK. Endothelial endothelin-1 over-expression using receptor tyrosine kinase tie-1promoter leads to more severe vascular permeability and blood brain barrier breakdown after transient middle cerebral artery occlusion. Brain Res. 2009 Apr 17;1266:121-9. Epub 2009 Feb 20.

6. Yeung PK, Lo AC, Leung JW, Chung SS, Chung SK. Targeted overexpression of endothelin-1 in astrocytes leads to more severe cytotoxic brain edema and higher mortality. J Cereb Blood Flow Metab. 2009        

7. Yau TO, Leung TH, Lam S, Cheung OF, Tung EK, Khong PL, Lam A, Chung S, Ng IO, Deleted in liver cancer 2 (DLC2) was dispensable for development and its deficiency did not aggravate hepatocarcinogenesis. PLoS One. 2009 Aug 10;4(8):e6566.                    

8. Li Q, Cheung C, Wei R, Hui ES, Feldon J, Meyer U, Chung S, Chua SE, Sham PC, Wu EX, McAlonan GM. Prenatal immune challenge is an environmental risk factor for brain and behavior change relevant to schizophrenia: evidence from MRI in a mouse model. PLoS One. 2009 Jul 24;4(7):e6354

9. Tong EH, Guo JJ, Xu SX, Mak K, Chung SK, Chung SS, Huang AL, Ko BC.Inducible nucleosome depletion at OREBP-binding-sites by hypertonic stress. PLoS One. 2009 Dec 24;4(12):e8435.

10. Tang WH, Kravtsov GM, Sauert M, Tong XY, Hou XY, Wong TM, Chung SK, Man Chung SS. Polyol pathway impairs the function of SERCA and RyR in ischemic-reperfused rat hearts by increasing oxidative modifications of these proteins J Mol Cell Cardiol. Dec 16. (Epub ahead of print) 2009

11. Yuk Shan Chen, Stephen S.M. Chung and Sookja K. Chung Aldose reductase deficiency improves Wallerian degeneration and nerve regeneration in diabetic mice assessed in YFP-labeled nerves, accepted by Journal of Neuropathology and Experimental Neurology, In Press

12. Yeung, Chung-Man; Lo, Amy; Cheung, Alvin; Chung, Stephen; Wong, David; Chung, Sookja K., More severe type 2 diabetes-associated ischemic stroke injury is alleviated in aldose reductase-deficient mice, accepted by J Neursci Res, In Press

13. Soroku Yagihashi, Hiroki Mizukami, Saori Ogasawara, Shin-Ichiro Yamagishi, Hitoshi Nukada, Noriaki Kato, Chihiro Hibi. Sookja Chung, Stephen Chung, Involvement of polyol pathway in myonephropathic metabolic syndrome (acute kidney injury) caused by hindlimb ischemia in mice and the effects of aldose reductase inhibitor, In Press

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