I received my BSc training in Biochemistry at the Chinese
University of Hong Kong, where I became particularly
interested in the fields of neuroscience and neuroimmunology.
Then, I pursued my MPhil training in neurochemistry and
neuroanatomy at the same university. Afterwards, I obtained a
research scholarship by Deutscher Akademischer Austauschdienst
(German Academic Exchange Service) to pursue my doctoral
training in neurophysiology and clinical neuroscience at the
Institute for Surgical Research at the Ludwig Maximilians
University (University of Munich), Germany. Then, I continued
my postdoctoral training in neuropharmacology and molecular
neuroscience at the National Institute of Environmental Health
Sciences, USA. During that time, I received the Visiting
Research Fellowship Award and the NIH Fellow Award for
Research Excellence by the National Institutes of Health. I
joined The University of Hong Kong in the summer of 2000 as a
research officer. Then, I was promoted to Research Assistant
Professor, Assistant Professor, and now Associate Professor.
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Laboratory of Neurodegenerative Diseases
Mission of the Laboratory:
To elucidate the molecular mechanisms of neuronal death in
aging-related neurodegenerative diseases in order to develop
Focuses of Research:
Molecular Mechanisms of Neuronal Degeneration (neuronal
apoptosis, autophagy, synaptic degeneration &
dysfunction of axonal transport) and Pharmacological
Intervention including herbal medicine in Neurodegenerative
Impact of Immune Responses in Neurological Disorders such as Alzheimer's Disease and Glaucoma
- Elucidating the biological mechanisms of different risks factors leading to neurodegeneration and how to prevent different risk factors
Summary of Research:
Molecular signaling of neuronal apoptosis, autophagy, synaptic degeneration and blockage of axonal transport.
My research interest is to study the molecular signaling pathways of neuronal death in neurodegenerative disease such as Alzheimer's disease. It has been demonstrated that postmortem human brain section displays activated caspases, suggesting that neuronal apoptosis occurs in Alzheimer's disease. We (Laboratory of Neurodegenerative Diseases) are the first to show that a novel double-stranded RNA-dependent protein kinase (PKR) is involved in
beta-amyloid peptide-induced neuronal apoptosis. Although it is originally named as double-stranded RNA-dependent protein kinase, recent findings have shown that PKR is a stress kinase for different stress signals. PKR is not simply involved in neuronal apoptosis; it also plays significant roles in the highly regulated degenerative processes. Apart from PKR, a major on-going project in our laboratory is to elucidate and map out how intracellular organelles such as endoplasmic reticulum (ER) and mitochondria are affected by low molecular weight
beta-amyloid (Abeta) peptides, resulting in either autophagy or neuronal apoptosis. In addition, we are now investigating the signaling events leading to autophagic neuronal death and synaptic degeneration. Understanding of the molecular signaling pathways will definitely pave a road for a better therapeutic strategy against neurodegenerative diseases.
Cell-cell Interactions of glial cells on disease progression of neurodegeneration.
Apart from the signaling pathways within neurons, cell-cell interaction between glia and neurons is also an important target for the therapy of neurodegenerative diseases. For example, how immune responses in the central nervous system affect the fate of neurons in various neurodegenerative diseases, such as Alzheimer's disease, Parkinson's disease and glaucoma is another thematic study in our group. Immune responses do not often occur in the brain, but only in the presence of potent immune stimulants or neuronal injuries. Innate immune components such as microglial cells are affected by normal neurotransmission and neurons. One of our research topics is to study how immune responses of glial cells in the eye affect the degeneration of retinal ganglion cells in glaucoma.
Pharmacological targeting and drug discovery from herbal medicine for neurodegenerative diseases
With all the above basic science studies, we are able to engage in applied research in searching for neuroprotective agents from Chinese medicine to natural products. Through the collaboration with colleagues in School of Biological Science and Department of Chemistry, we have identified several compounds that have high potentials to be neuroprotective agents. We are attempting to develop and commercialize some of the products into pharmaceutical market. We believe that prevention of neurodegeneration is better than treatment.
Pathophysiological mechanisms of risk factors leading to aging-associated neurodegeneration
In recent years, we are particularly interested in understanding the pathophysiological mechanisms of different risk factors leading to neurodegenerative diseases. Epidemiological studies have shown that repeated episodes of depression can lead to neurodegeneration in the hippocampus. We have demonstrated that depression can be considered to be a type of neurodegeneration leading to atrophy of hippocampus. We are actively investigating how depression leads to neurodegeneration in Alzheimer's disease. Apart from depression, we are also investigating high-fat diet, hypertension, cigarette smoking and systemic inflammation. All these studies will advance our knowledge of how different factors lead to aging-associated neurodegeneration, and how we can prevent neurodegeneration
Pathophysiological changes of retina to inform disease progression in the brain
Our laboratory has been investigating pathological changes in the retina of Alzheimer's disease. We could find accumulation of
beta-amyloid peptide and hyper-phosphorylation of tau protein in the retina of transgenic mice in Alzheimer's disease. On the other hand, we could find similar pathology in glaucoma and aging-related macular degeneration. We propose that high level of
beta-amyloid peptide can be a pathological factor triggering neurodegeneration in different forms of glaucoma. We are investigating the similarity of their pathologies so that our eyes can be a window for monitoring disease progression and efficacy of therapeutic intervention. This is a novel concept in neurodegenerative disease research.
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(since 2000 the year I joined HKU, *correspondence author)
Alzheimerís Disease Research and Drug Discovery in this Area:
K., Chan, T. F., Wu, A., Leung, I. Y. P., So, K. F., Chang, R. C. C.*
(2012) Neurodegeneration in the retina of mouse models of Alzheimer's disease: what can we learn from the retina?
AGE (Journal of American Aging Association), 34,
Y. S., Yang, X. F., Yeung, S. C., Chiu, K., Lau, C. F., Tsang, A. W. T., Mak, J. C. W.,
Chang, R. C. C.* (2012) Cigarette smoking accelerated brain aging and induced pre-Alzheimer-like neuropathology in rats.
PloS One, 7(5), e36752.
Y. S., Yang, X. F., Lau, J. C. F., Hung, C. H. L., Wuwongse, S., Zhang, Q., Wang, J. Z., Baum, L., So, K. F. and
Chang, R. C. C.* (2012) Endoplasmic reticulum stress induces tau pathology and forms a vicious cycle: Implication in Alzheimer's disease pathogenesis.
J. Alz. Dis., 28, 839-854.
Chang, R. C. C., Chu, L. W., Mak, H. K. F. (2012) Current imaging techniques in Alzheimer's disease and applications in animal models.
Am. J. Nucl. Mol. Imaging, 2, 391-409.
Y.S., So, K. F. and Chang, R. C. C.* (2011) Drug discovery from Chinese Medicine against neurodegeneration in Alzheimer's and vascular dementia.
Chinese Medicine, 6:15.
Cheung, Y. T., Zhang, N. Q., Hung, C. H. L., Lai, C. S. W., Yu, M. S., So, K. F. and
Chang, R. C. C.* (2011) Temporal relationships of autophagy and neuronal apoptosis in low molecular weight
beta-amyloid peptide neurotoxicity.
J. Cell. Mol. Med., 15, 244-257.
Hung, C. H. L., Ho, Y. S. and
Chang, R. C. C.* (2010) Modulation of mitochondrial calcium as a pharmacological target for Alzheimer's disease.
Ageing Res. Rev., 9, 447-456.
Chang, R. C.
C.*, Ho, Y. S., Yu, M. S., So, K. F. (2010) Medicinal and nutraceutical uses of wolfberry in preventing neurodegeneration in Alzheimer's disease. In: Charles Ramassamy and
Stephane Bastianetto Eds.
Recent Advances on Nutrition and Alzheimer's disease. (Book Chapter). pp169-185.
Chang, R. C.
C.*, Chao, J., Yu, M. S., Wang, M. (2010) Neuroprotective effects of oxyresveratrol from fruit against neurodegeneration in Alzheimer's disease. In: Charles Ramassamy and
Stephane Bastianetto Eds.
Recent Advances on Nutrition and Alzheimer's disease. (Book Chapter). pp155-168.
Ho, Y. S., Yu, M. S., Yang, X., So, K. F., Yuen, W. H., Chang, R. C. C.*
(2010) Neuroprotective effects of polysaccharides from Wolfberry antagonize homocysteine-induced toxicity in rat cortical neurons. J.
Alz. Dis., 19, 813-827.
Yu, J. T., Chang, R. C.
C., Tan, L. (2009) Calcium dysfunction in Alzheimer's disease: From basic mechanisms to therapeutic opportunities.
Prog. Neurobiol., 89, 240-255.
J., Paquet, C.,
Chang, R. C. C. (2009) Could PKR inhibition modulate human neurodegeneration?
Expert Rev. Neurother., 9, 1455-1457.
Lai, C. S. W., Preisler, J., Baum, L., Lee, D. H. S., Ng, H. K., Hugon, J., So, K.
F., Chang, R. C. C.* (2009) Low molecular weight
A-beta induces collapse of endoplasmic reticulum.
Mol. Cell. Neurosci., 41, 32-43.
Ho, Y. S., Yik, S. Y., Yu, M. S., So, K. F., Yuen, W. H.,
Chang, R. C. C.* (2009) Anti-aging Lycium barbarum antagonizes glutamate excitotoxicity in rat cortical neurons.
Cell. Mol. Neurobiol., 29, 1233-1244.
Lai, C. S. W., Yu, M. S., Yuen, W. H., So, K. F., Zee, S. Y.,
Chang, R. C. C.* (2008) Neuroprotective effects of anti-aging fungus Gandoderma lucidum.
Brain Res., 1190, 215-224.
Chang, R. C.
C.*, Yu, M. S., Lai, C. S. W. (2007) Significance of molecular signaling for protein translation control in neurodegenerative diseases.
Neurosignals, 15, 249-258. (invited review)
Yu, M. S., Lai, C. S. W., Ho, Y. S., Zee, S. Y., So, K. F., Yuen, W. H. and
Chang, R. C. C.* (2007) Characterization of the effects of anti-aging medicine Fructus Lycii on ?-amyloid peptide neurotoxicity.
Intl. J. Mol. Med., 20,
Yu, M. S., Wong, A. Y. Y., So, K. F., Fang, J. N., Yuen, W. H.,
Chang, R. C. C.* (2007) New polysaccharide from Nerium indicum protects neurons via stress kinase signaling pathway.
Brain Res., 1153, 221-230.
Ho, Y. S., Yu, M. S., Lai, C. S. W., So, K. F., Yuen, W. H.,
Chang, R. C. C.* (2007) Characterizing the neuroprotective effects of alkaline extract of Lycium barbarum on ?-amyloid peptide neurotoxicity.
Brain Res., 1158, 123-134.
Chiu, K., Lau, W. M., Lau, H. T., So, K. F., Chang, R. C. C.*
(2007) Micro-dissection of rat brain for RNA and protein extraction from specific brain region.
J. Vis. Exp., (08/30/07) 7, http://www.jove.com/index/Details.stp?ID=269.
Yu, M. S., Suen, K. C., Kwok, N. S., So, K. F., Hugon, J.,
Chang, R. C. C.* (2006) Beta-amyloid peptide induces neuronal apoptosis via a mechanism independent of unfolded protein responses.
Apoptosis, 11, 687-700.
Lai, S. W., Yu, M. S., Yuen, W. H.,
Chang, R. C. C.* (2006) Novel neuroprotective effects of the aqueous extracts from Verbena officinalis Linn. Neuropharmacology 50, 641-650.
Yu, M. S., Leung, S. K. Y., Che, C. M., Zee, S. Y., So, K. F., Yuen, W. H.,
Chang, R. C. C.* (2005) Neuroprotective effects of an anti-aging Chinese medicine Lycium barbarum against
beta-amyloid peptide neurotoxicity.
Exp. Geronotol.40, 716-727.
Lin, K. F.,
Chang, R. C. C., Suen, K. C., So, K. F., Hugon, J. (2004) Modulation of calcium/calmodulin kinase II attenuates
beta-amyloid peptide-induced neurotoxicity.
Eur. J. Neurosci. 19, 2047-2055.
Yu, M. S., Lai, S. W., Lin, K. F., Fang, J. N., Yuen, W. H.,
Chang, R. C. C.* (2004) Characterization of polysaccharides from the flowers of Nerium indicum and their neuroprotective effects.
Intl. J. Mol. Med., 14, 917-924.
Suen, K. C., Yu, M. S., So, K. F.,
Chang, R. C. C.*, Hugon, J. (2003) The upstream pathway of double-stranded RNA-dependent serine/threonine kinase activation in neurons exposed to
beta-amyloid peptide neurotoxicity.
J. Biol. Chem. 278,
Suen, K. C., Elyaman, W., Lin, K. F., So, K. F.
Chang, R. C. C.*, Hugon, J. (2003) Reduction of intracellular calcium increase provides partial neuroprotection against
beta-amyloid peptide toxicity, significance of endoplasmic reticulum stress. J.
Neurochem. 87, 1413-1426.
Chang, R. C.
C., Suen, K. C., Ma, C. H., Elyaman, W., Ng, H. K., Hugon, J.
(2002) Involvement of double-stranded RNA-dependent protein kinase and phosphorylation of eukaryotic initiation factor 2alpha in neuronal degeneration.
J. Neurochem. 83, 1215-1225.
Chang, R. C. C., Wong, A. K. Y., Ng, H. K., Hugon, J.
(2002) Phosphorylation of eukaryotic initiation factor-2a (eIF2a) is associated with neuronal degeneration in Alzheimer's disease.
NeuroReport 13, 2429-2432.
Elyaman, W., Terro, F., Suen, K. C., Yardin, C. Chang, R. C.
Hugon, J. (2002) BAD and Bcl-2 regulation are early events linking neuronal endoplasmic reticulum stress to mitochondria-mediated apoptosis.
Mol. Brain Res. 109: 233-238.
in Glaucoma Research and Drug Discovery in this Area:
Ho, W. L., Leung, Y., Tsang, A. W. T., So, K. F., Chiu, K.,
Chang, R. C. C.* (2013) Tauopathy in the retina and optic nerve: Does it shadow pathological changes in the brain? Mol.
Vision, 18, 2700-2710.
Chiu, K., So, K. F.,
Chang, R. C. C.* (2013) Progressive neurodegeneration of retina in Alzheimer's disease: Are
beta-amyloid peptide and tau new pathological factors in glaucoma? In Shimon Rumelt edit:
InTech Open Assess Publisher (Book Chapter), Chapter 8, 157-177. (ISBN 978-953-51-1064-4;
Chan, T. F., Chiu, K., Lok, C. K. M., Lau, H. W., So, K. F., Chang, R. C. C.*
(2012) Morphometric analysis of retinal sections. J.
Vis. Exp., pii3377, DOI:10.3791/3377.
X.S., Feng Q., Lo A. C. Y, Chang R. C. C., Lin B., Chung S. K.,
So K. F. (2012) Protection of retinal ganglion cells and retinal vasculature by Lycium barbarum Polysaccharides in a mouse model of acute ocular hypertension.
PloS One, 7, e45469.
Mi, X. S., Chiu, K., Van, G., Leung, J. W. C., Lo, A. C. Y., Chung, S. K.,
Chang, R. C. C., So, K. F. (2012) Effect of Lycium barbarum polysaccharides on the expression of endothelin-1 and its receptors in an ocular hypertension model of rat glaucoma.
Neural Regen. Res., 7,
Chiu, K., So, K. F.,
Chang, R. C. C.* (2011) Immune modulation in glaucoma - can manipulation on microglia activation help? In: Martin Kofronova & Tomas Kubena Eds. The Mystery of Glaucoma; InTech
Open Access Publisher (Book Chapter). Chapter 14, 257-268. (ISBN 978-953-307-567-9)
Chiu, K., Liang, Y. X.,
Chang, R. C. C., So, K. F. (2011) Lycium barbarum L.: a neuroprotective drug for
glaucoma枸杞子 - 青光眼的神經保護劑.
Ophthalmol. CHN. (眼科), 20,
Li, S. Y., Yang, D., Yeung, C. M., Yu, W. Y.,
Chang, R. C. C., So, K. F., Wong, D., Lo, A. C. Y. (2011) Lycium Barbarum polysaccharides reduce neuronal damage, blood-retinal barrier disruption and oxidative stress in retinal ischemia/reperfusion injury.
PloS One, e16380.
So, K. F.,
Chang, R. C .C. (2010) Ginseng, Wolfberry, Bilberry in
"Section 8: Non-pharmaceutical Medications and Approaches". In: R.N. Weinreb & J. Liebmann Eds.
Medical Treatment of Glaucoma: World Glaucoma Association Consensus Series 7. Kugler Publication (Book Chapter)
Chiu, K., Zhou, Y., Yeung, S. C., Lok, C. K. M., Chan, O. O. C.,
Chang, R. C. C.*, So, K. F., Chiu, J. F. (2010) Up-regulation of crystallins is involved in neuroprotective effects of Wolfberry on survival of retinal ganglion cells in rat ocular hypertension model.
J. Cell. Biochem., 110, 311-320.
Chiu, K., Yeung, S. C., So, K. F.,
Chang, R. C. C.* (2010) Modulation of morphological changes of microglia and neuroprotection by monocyte chemoattractant protein-1 in experimental glaucoma.
Cell. Mol. Immunol., 7, 61-68.
Chiu, K., Chan, H. C., Yeung, S. C., Yuen, W. H., Zee, S. Y.,
Chang, R. C. C.*, So, K. F. (2009) Modulation of microglia by Wolfberry on the survival of retinal ganglion cells in a rat ocular hypertension model.
J. Ocular Biol. Dis. Informatics, 2, 127-136.
Chiu, K., Lau, W. M., Yeung, S. C., Chang, R. C.
C.*, So, K. F. (2008) Retrograde labeling of retinal ganglion cells by application of Fluoro-Gold on the surface of superior colliculus.
J. Vis. Exp., (06/01/08) 16,
Chan, H. C., Chang, R. C. C., Ip, A. K. C., Chiu, K., Yuen, W. H., Zee, S. Y., So, K. F.
(2007) Neuroprotective effects of Lycium barbarum Lynn, a traditional Chinese herbal medicine in protecting retinal ganglion cells in an ocular hypertension model of glaucoma.
Exp. Neurol., 203, 269-273.
Chiu, K., Chang, R. C. C.*, So, K. F. (2007) Laser induced chronic ocular hypertension model on SD rats. J. Vis.
Exp., (12/01/07) 10,
Chiu, K., Chang, R. C. C.*, So, K. F.
(2007) Intravitreous injection for establishing ocular disease model.
J. Vis. Exp., (10/01/07) 8, http://www.jove.com/index/Details.stp?ID=313.
Parkinsonís Disease Research and Drug Discovery in this Area:
Chao J, Leung Y, Wang M,
Chang, R. C. C.* (2012) Nutraceuticals and their preventive or potential therapeutic value for Parkinson's disease.
Nutr. Rev., 70, 373-386.
Chao, J., Lau, K. W., Huie, M. J., Ho, Y. S., Yu, M. S., Lai C. S. W., Wang, M., Yuen, W. H., Lam, W. H., Chan, T. H.,
Chang, R. C. C.* (2010) A pro-drug of the green tea polyphenol (-)-epigallocatechin-3-gallate (EGCG) prevents differentiated SH-SY5Y cells from toxicity induced by 6-hydroxydopamine.
Neurosci. Letters, 469, 360-364.
Chao, J., Li, H., Cheng, K. W., Yu, M. S., Chang, R. C.
C.*, Wang, M. (2010) Protective effects of pinostilbene, a resveratrol methylated derivative, against 6-hydroxydopamine-induced neurotoxicity in SH-SY5Y cells. J. Nutr. Biochem., 21, 482-489.
Cheung, Y. T., Lau, W. K. W., Chang, R. C. C.* (2010) What do we need to concern in using cell line for neurotoxicology research, differentiation or disturbance of intracellular signaling?
NeuroToxicology, 31, 164-166. (Letter to Editor)
Cheung, Y. T., Lau, W. K. W., Yu, M. S., Lai, C. S. W., Yeung, S. Z., So, K. F.,
Chang, R. C. C.* (2009) Effects of all-trans retinoic acid on human neuroblastoma SH-SY5Y as in vitro model of neurotoxicity research.
NeuroToxicology, 30, 127-135.
Chao, J., Yu, M. S., Ho, Y. S., Wang, M.,
Chang, R. C. C.* (2008) Oxyresveratrol prevents Parkinsonian mimetic 6-hydroxydopamine neurotoxicity.
Free Radic. Biol. Med., 45,
Depression in Neurodegenerative Diseases and Drug Discovery in this area:
Wong, G. T. S.,
Chang, R. C. C.*, Law, A. C. K. (2013) A breach in the scaffold: The possible role of cytoskeleton dysfunction in the pathogenesis of major depression.
Ageing Res. Rev., 12, 67-75.
Zhang, E., Yau, S. Y., Lau, B. W. M., Ma, H., Lee, T. M. C.,
Chang, R. C. C.*, So KF (2012) Synaptic plasticity, but not hippocampal neurogenesis mediated the counteractive effect of Wolfberry on depression in rats.
Cell Transplant., 21, 2635-2649.
Lau, B. W. M., Lee, C. D., Li, Y., Fung, S. M. Y., Sang, Y. H., Shen, J.,
Chang, R. C. C., So, K. F. (2012) Polysaccharides from Wolfberry prevents corticosterone-induced inhibition of sexual behavior and increases neurogenesis. PloS
One, 7, e33374.
Lau, B. W., Ren, C., Yang, J., Yan, S. W.,
Chang, R. C. C., Pu, M., So, K. F. (2011) Light deprivation induces depression-like behavior and suppresses neurogenesis in diurnal Mongolian gerbil (Meriones unguiculatus). Cell
Transplant., 20, 871-881.
Chang, R. C. C.*, Law, A. C. K. (2010) The putative neurodegenerative links between depression and Alzheimer's disease. Prog. Neurobiol., 91, 362-375.
Herbal Medicine Research in Aging and Aging-related
Ho, Y. S., Hung, C. H. L.,
Chang, R. C. C.* (2013) Green tea and neurodegeneration in Alzheimer's disease. In: Victor R. Preedy Ed.
Tea in Health and Disease Prevention Elsevier Publisher (Book Chapter). Chapter 58,
Ho YS, Poon DCH, Chan TF,
Chang R. C. C.* (2012) From small to big molecules: how do we prevent and delay progression of aging-related neurodegeneration?
Curr. Pharmaceut. Design, 18, 15-26.
Ho, Y. S., Chiu, K., Hung, C. H. L.,
Chang, R. C. C.* (2011) Holistic approach versus scientific evidence, what do we know about anti-aging herbal medicine in aging-associated neurodegenerative diseases? In Akhlaq A. Farooqui Ed: Phytochemicals and Human Health: Pharmacological and Molecular Aspects. (Book Chapter) Chapter 6, p157-186.
Ho, Y. S., So, K. F.,
Chang, R. C. C.* (2010) Anti-aging herbal medicine - how and why can they be used in aging-associated neurodegenerative diseases?
Ageing Res. Rev., 9, 354-362.
Chang, R. C.
C.*, So, K. F. (2008) Use of anti-aging herbal medicine, Lycium barbarum, against aging-associated diseases. What do we know so far?
Cell. Mol. Neurobiol., 28, 643-652. (Invited review)
Sze, S. C. W., Song, J.,
Chang, R. C. C., Zhang, K. Y., Wong, R. N. S., Yao, T.
(2008) Recent advances on anti-aging profile of Fructus Lycii: An ancient Chinese herbal medicine.
J. Compl. Alt. Med., 5, (1), Article 8. Available at: http://www.bepress.com/jcim/vol5/iss1/8.
Chang, M. P.,
Chang, R. C. C., Wang, M., So, K. F. (2008) A review on the laboratory investigations and epidemiological studies of black tea, In: Chi-Tang Ho, James E. Simon, Fereidoon Shahidi and Yu Shao, ACS Symposium Series 987, Dietary
Supplements. Washington, DC, American Chemical Society. (Book chapter)
Yu, M. S., Ho, Y. S., So, K. F., Yuen, W. H.,
Chang, R. C. C.* (2006) Cytoprotective effects of Lycium barbarum against reducing stress on endoplasmic reticulum.
Intl. J. Mol. Med., 17, 1157-1162.
Chang, R. C. C.* Yuen, W. H., Zee, S. Y. (2005) Immune modulatory effects of Prunella Valgaris L.
Intl. J. Mol. Med. 15, 491-496.
Fang, X., Yu, M. S., Yuen, W. H., Zee, S. Y.,
Chang, R. C. C.* (2005) Immune modulatory effects of Prunella Valgaris L. on monocytes/macrophages. Intl.
J. Mol. Med., 16, 1109-1116.
Neuroimmunology / Neuroinflammation in Neurodegenerative Diseases and Drug Discovery:
Poon, D. C. H., Ho, Y. S., Chiu, K.,
Chang, R. C. C.* (2013) Cytokines: how important are they in mediating sickness?
Neurosci. Biobehav. Rev., 37, 1-10.
Yik, S. Y., Yu, M. S., Ho, Y. S., Lai, C. S., Cheung, Y. T., So, K. F.,
Chang, R. C. C.* (2012) Neuroprotective effects of minocycline on double-stranded RNA-induced neurotoxicity in cultured cortical neurons. Hong Kong Med. J., Suppl. 2, 42-44.
Chang, R. C.
C.*, Chiu, K., Ho, Y. S., So, K. F. (2009) Modulation of neuroimmune responses on glia in the central nervous system: implication in therapeutic intervention against neuroinflammation.
Cell. Mol. Immunol., 6,
Jeohn, G. H., Cooper, C., Wilson, B.,
Chang, R. C. C., Jang, K., Kim, H. Liu, B., Hong, J. S.
(2002): p38 kinase is involved in LPS-induced dopaminergic neuronal cell death in rat mescenphalic neuron-glia cultures. Ann. N.Y. Acad. Sci. 962:
Chang, R. C. C., Tsang, D., Stadlin, A. (2001): The effects of tumor necrosis factor alpha on taurine uptake in cultured rat astrocytes.
Neurochem. Intl. 38: 251-256.
Chang, R. C.
C.*, Chen, W., Hudson, P., Wilson, B., Han, S. K., Hong, J. S.
(2001) Neurons reduce glial responses to lipopolysaccharide (LPS) and prevent injury of microglial cells from over-activation by LPS.
J. Neurochem. 76: 1042-1049.
Chang, R. C.
C., Hudson, P., Wilson, B., Haddon, L., Hong J. S. (2000) Influence of neurons on lipopolysaccharide-stimulated production of nitric oxide and tumor necrosis factor-? by glia.
Brain Res. 853:
Chang, R. C. C., Hudson, P., Wilson, B., Liu, B., Abel, H. and Hong, J. S.
(2000) High concentrations of extracellular potassium enhance bacterial endotoxin lipopolysaccharide-induced neurotoxicity. Neuroscience 97: 757-764.
Chang, R. C.
C.*, Hudson, P., Wilson, B., Liu, B., Abel, H., Hemperly, J., Hong, J. S.
(2000) Immune modulatory effect of neural cell adhesion molecules on lipopolysaccharide-stimulated nitric oxide production by cultured glia. Mol. Brain Res. 81: 197-201.
Chang, R. C. C., Rota, C., Glover, R., Mason, R., Hong, J. S.
(2000) A novel effect of opioid receptor antagonist naloxone on the production of reactive oxygen species by microglia: A study of free radical by electroparamagnetic resonance.
Brain Res. 854: 224-229.
Liu, B., Du, L., Kong, L. Y., Hudson, P. M., Wilson, B. C.,
Chang, R. C., Abel, H. and Hong, J. S. (2000) Reduction of lipopolysaccharide induced- and microglial activation mediated-neurotoxicity in mouse cortical neuron-glia co-cultures by naloxone.
Jeohn, G. H.,
Chang, R. C. C., Kim W. G., Wilson, B., Mohney R. P., Wetsel, W. C. and Hong, J. S.
(2000) Post-transcriptional inhibition of lipopolysaccharide-induced expression of inducible nitric oxide synthase by
Go6976 in murine microglia.
Mol. Brain Res. 79: 18-31.
Other Collaborative Research:
Xiao, J., Guo, R., Fung, M. L., Liong, E.,
Chang, R. C. C., Ching, Y. P., Tipoe, G. (2013) Garlic derived S-allylmercaptocysteine (SAMC) ameliorates non-alcoholic fatty liver disease (NAFLD) in a rat model through inhibition of apoptosis and enhancing autophagy. Evid-Based Complement.
Altern. Med., In press.
Chiu, P. W., Mak, H. K. F., Yau, K. K. W., Chan, Q.,
Chang, R. C. C., Chu, L. W. (2013) Metabolic changes in anterior and posterior cingulate cortices of the normal aging brain: Proton magnetic resonance spectroscopy study at 3 Tesla.
AGE (Journal of American Aging Association), In press.
Zhang, Y. K., Wang, J., Liu, L.,
Chang, R. C. C., So, K. F., Ju, G. (2013) The effect of Lycium barbarum on spinal cord injury, particularly its relationship with M1 and M2 macrophage in rats.
BMC Complement. Altern. Med., 13, 67.
Klionsky, D. J., Abdalla, F. C.,
Chang, R. C. C., Che, C. M., Zuckerbraun, B. (2012) Guidelines for the use and interpretation of assays for monitoring autophagy.
Autophagy, 8, 445-554. (more than 100 authors to launch the guideline for monitoring autophagy)
Yang, D., Li, S. Y., Yeung, C. M.,
Chang, R. C. C., So, K. F., Wong, D., Lo, A. C. Y. (2012) Lycium barbarum extracts protect the brain from blood-brain-barrier disruption and cerebral edema in experimental stroke.
PloS One, 7, e33596.
Xiao, J., Liong, E. C., Ching, Y. P.,
Chang, R. C. C., So, K. F., Fung, M. L., Tipoe, G. L.
(2012) Lycium barbarum polysaccharides protect mice liver from carbon tetrachloride-induced oxidative stress and necroinflammation.
J. Ethnopharmacol., 139, 462-470.
Zhu Q, Zhang NQ, Lau CF, Chao J, Sun Z,
Chang RCC, Chen F, Wang M (2012) In vitro attenuation of acrolein-induced toxicity by phloretin, a phenolic compound from apple. Food Chem., 135, 1762-1768.
Zheng, Z. P., Ma, J., Cheng, K. W., Chao, J., Zhu, Q.,
Chang, R. C. C., Zhao, M., Lin, Z. X., Wang, M. (2010) Sulfur-containing constituents and one 1H-pyrrole-2-carboxylic acid derivative from pineapple [Ananas comosus (L.) Merr.] fruit.
Phytochemistry, 17-18, 2046-2051.
Peng, X., Ma, J., Chao, J., Sun, Z.,
Chang, R. C. C., Tse, I., Li, E. T., Chen, F., Wang, M.
(2010) Beneficial effects of cinnamon proanthocyanidins on the formation of specific advanced glycation endproducts and methylglyoxal-induced impairment on glucose consumption.
J. Agric. Food Chem., 58, 6692-6696.
Yu, H. T., Chan, W. W. L., Chai, K. H., Lee. C. W. C.,
Chang, R. C. C., Yu, M. S., McLoughlin, D. M., Miller, C. C. J., Lau, K. F.
(2010) Transcriptional regulation of human FE65, a ligand of Alzheimer's disease amyloid precursor protein, by Sp1. J.
Cell Biochem., 109, 782-783.
Lau, K. F., Chan, W. M., Perkinton, M. S., Tudor, E. L.,
Chang, R. C. C., Chan, H. Y. E., McLoughlin, D. M., Miller, C. C. J.
(2008) Derax1 interacts with Fe65 to regulate Fe65-amyloid precursor protein dependent transcription.
J. Biol. Chem., 283: 34728-34737.
Wong, H. K., Wang, X.,
Chang, R. C. C., Feng, H., Wang, Q., Lo, K. W., Huang, D. P., Yuen, P. W., Wong, Y. C., Tsao, S. W.
(2005) Stable expression of EBERs in immortalized nasopharyngeal epithelial cells confers resistance to apoptotic stress.
Mol. Carcinogen., 44: 92-101.
Chang, R. C. C., Staub, F., Baethmann, A., Plesnila, N.
(2000) The contribution of anion transporters to the acidosis-induced swelling and intracellular acidification of glial cells.
"Advanced Understanding of Neurodegenerative Diseases",
(2011) edited by Raymond Chuen-Chung CHANG. (by invitation to be editor) InTech Open Access Publisher, ISBN 978-953-307-485-6.
"Neurodegenerative Diseases - Processes, Prevention, Protection and Monitoring",
(2011) edited by Raymond Chuen-Chung CHANG. (by invitation to be editor)
InTech Open Access Publisher, ISBN 978-953-307-529-7. (http://www.intechopen.com/books/show/title/neurodegenerative-diseases-processes-prevention-protection-and-monitoring)
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Section Editor "Natural Medicine", Journal of Neuroimmune Pharmacology
Associate Editor, Journal of Alzheimer's Disease
American Journal of Alzheimer's Disease and Related Dementia
Advance in Alzheime's Disease
Asia Journal of Neuroscience
Journal of Brain and Behavioral Sciences
Neural Regeneration Research
Dataset Paper in Neuroscience
Dataset Paper in Medicine (Ophthalmology)
International Journal of Clinical and Experimental Medicine
Anatomy & Physiology: Current Research
The Open Enzyme Inhibition Journal
Dr. Chang is a founding member and secretary of HKU
Alzheime's Disease Research Network, aiming to bridge all investigators in HKU for Alzheimer's disease research. Besides collaborations within the department and with other departments at HKU, collaborative efforts have been made with other local universities such as the Chinese University of the Hong Kong (Dr. KF Lau, Dr. Larry Baum and Prof. HK Ng). In addition, collaboration is also continued with research groups at the National Institutes of Health, USA; Professor Philip Wong at Department of Pathology/Alzheimer Disease Research Centre, John Hopkins University, USA; Professor Jacques Hugon at Alzheimer Clinical Centre, University of Paris 7, France; Professor Jianzhi Wang at Pathophysiology Department, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China; Professor Weidong Le at Institute of Health Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, and Jiao Tong University School of Medicine, Shanghai, China; Dr. Xifei Yang at Shenzhen Centre for Diseases Control and Prevention, Shenzhen, China; Professors JZ Ni and Qiong Liu at the College of Life Sciences, Shenzhen University, Shenzhen, China. Apart from research, the laboratory actively engages in neuroscience education in high school (secondary school in Hong Kong). Together with Dr. Andrew Suen at Po Leung Kuk Laws Foundation College, Hong Kong, we have established research oriented educational program to teach and nurture our future young neuroscientists in Hong Kong in neurodegenerative diseases research. Our effort has been awarded by Society for Neuroscience for the Neuroscientist-Teacher Partner Award in 2006.
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