Michael Shing-Yan Huen (禤承恩)
Assistant Professor
B.Sc., M.Phil. (HKUST), Ph.D. (HKU)

Department of Anatomy and Centre for Cancer Research
1/F. Laboratory Block
Faculty of Medicine Building
21 Sassoon Road, Hong Kong

Anatomy Office: (852) 2819-2868 (voice)
Anatomy Office: (852) 2817-0857 (fax)

E-mail: huen.michael@hku.hk

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Background

Academic qualifications

Anna Fuller Fund Fellow, Yale University, Connecticut, USA (2007-2009)
Doctor of Philosophy, The University of Hong Kong, Hong Kong (2002-2006)
Master of Philosophy, The Hong Kong University of Science and Technology, Hong Kong (2000-2002)
Bachelor of Science, The Hong Kong University of Science and Technology, Hong Kong (1997-2000)

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Research

DNA Damage Signaling & Repair

Our major research interest aims to understand how mammalian cells cope with genotoxic stress via evolutionarily conserved mechanisms, including cell cycle checkpoint control and DNA repair. The fact that our DNA is constantly challenged by a variety of mutagenic agents underscores the need for an efficient system to protect genome integrity, which is pivotal for faithful inheritance of our genetic materials. This system, collectively termed “The DNA Damage Response”, not only has been implicated as an anti-cancer barrier during early human tumorigenesis, but is also functionally coupled to diverse cellular processes, dysregulations of which contribute to human conditions ranging from aging-associated diseases and neurodegenerative disorders. Here, we use a combination of biochemical, and molecular and cell biology techniques to address how the components of the DNA Damage Response network is connected; how they sense and transmit DNA damage signals to orchestrate appropriate cellular protocols that, in concert, promote cell and organismal survival.

Contact Person
Michael S.Y. Huen, PhD
Genome Stability Research Laboratory
L1, Laboratory Block
21 Sassoon Road
Pokfulam, Hong Kong S.A.R.
Tel: (852)2819-2868
Fax: (852)2817-0857
Email: huen.michael@hku.hk
Lab Webpage: https://sites.google.com/site/huenlab/

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