Academic Staff > K. F. So

 

Kwok-Fai So ( 蘇國輝 )
Chair Professor
Jessie Ho Professor in Neuroscience
Ph.D. (M.I.T)

Department of Anatomy
1/F. Laboratory Block
Faculty of Medicine Building
21 Sassoon Road, Hong Kong

Anatomy Office: (852) 2819-9216 (voice)
Anatomy Office: (852) 2817-0857 (fax)

E-mail: hrmaskf@hkucc.hku.hk

Jump to: Background / Research / Publications / Collaborations

Background

Prof. So  is currently Chair Professor and Head of the Department of Anatomy, Jessie Ho Professor in Neuroscience at The University of Hong Kong ( http://www.hku.hk/anatomy/Staff/KFSo/k.f.so.htm ), a member of the Chinese Academy of Sciences, Co-Director of the China Spinal Cord Injury Network (www.hku.hk/hkuscif), and Co-Director of the State Key laboratory of Brain and Cognitive Sciences at HKU (www.hku.hk/fmri/).   He received his Ph.D. degree from MIT. He is one of the pioneers in the field of axonal regeneration in visual system. He was the first to show lengthy regeneration of retinal ganglion cells in adult mammals with peripheral nerve graft. He is currently using multiple approaches to promote axonal regeneration in the optic nerve and spinal cord. His team identifies neuroprotective and regenerative factors including: peptide nanofiber scaffold, trophic factors, herbal extracts, other small molecules, immune responses and environmental manipulation. He is the author and co-author of over 200+ publications.             . 

He is Honorary or Visiting Professor to a number of Universities in China, including the Sun Yat-Sen University (Guangzhou), Beijing Medical University, Institute of Neurosciences of the Fourth Military Medical University (Xi’an), Central South University (Changsha), Chengdu University of Traditional Chinese Medicine (Sichuan), Chengdu Army Kunming General Hospital (Kunming), Suzhou University, and Tianjin Medical University Hospital.

Back to top

Research

Neuroprotection and neuroregeneration of the mammalian optic nerve.

  • Long-term research goal is to find a cure for blindness resulted from traumatic optic nerve in glaucoma. Various approaches are used to promote the survival and axonal regeneration of retinal ganglion cells in hamster and rat.
     
  • Peripheral or optic nerve graft, Schwann cells or fibroblasts, and trophic factors such as BDNF, CNTF, Nogo, or Lingo receptor antagonists are administered into the vitreous of the eye to rescue damaged retinal ganglion cells.
     
  • Low level laser irradiation and traditional Chinese herbal extracts are also used to protect damaged retinal ganglion cells.
     
  • Peripheral nerve graft is used as a bridge to promote and guide the regeneration of the damaged optic nerve.
     
  • Injection of CNTF into the vitreous of the eye to promote regeneration of optic axons across a crushed site.
     
  • Use of self-assembling peptide nanofiber scaffold for axon regeneration and repair of injured brain tissue.
     
  • The molecular mechanisms of neuroprotection and neuroregeneration are studies including growth associated gene expression and trophic factors receptor genes.
     
  • The functional return of vision of the animals with repaired optic nerve is tested in our animal behavioral laboratory.

Postgraduate Students

A total of 40 graduate students have completed their research study [24 Ph.D. (16 as Principal Supervisor and 8 as Co-Supervisor), and 16 M.Phil/ MMS (7 as Principal Supervisor and 9 as Co-Supervisor)]. Most of them continue to engage in academic research, with two working as Associate Professor in Chinese University of Hong Kong, one as Associate Professor at Hong Kong Polytechnic University, one as the Professor of Anatomy Department at Peking University, one as the Associate Director at the Institute of Neuroscience of the 4th Military University in China, one as Instructor at Harvard Medical School, and one as Director of the Laboratory for Neural Repair at Shantou University Medical College.

Currently 22 graduate students, 11 for the Ph.D. (5 as PS, 6 as CS) and 11 as CS for the M.Phil and MMS programs.

Principal Supervisor Currently for:

Miss YAU Suk-Yu, MPhil, candidate, 1 Jan 2005-
Protective effect of exercise on corticosterone induced suppression of hippocampal cell proliferation

Mr. LAU Wui Man Benson, PhD candidate, Jan 2006-
Study of adult neurogenesis and molecular mechanism underlying sexual behavior in male rats following induction of depression-like behavior and pharmacological treatment

Mr. ZHANG Endong, PhD candidate, Sept 2006-
 Gouqizi and antidepression

Dr. MI Xuesong, PhD candidate, Sept 2007-
RAGE (receptor for advanced glycation end products), Abeta (betaamyloid peptide) and ET-1 (endothelin-1) – probing their effects in glaucoma with transgenic mice over-expressing ET-1 in endothelial or glial cells

Mr. LI Hong-ying, PhD candidate, Sept 2008-

 Ms LEUNG Yan Pui, Irene, MMS candidate, Jan 2007 (Partime)
 

Current Research Team Members

 Postdoctoral Research Fellows
- Dr. YANG Jian
- Dr. C. K. CHIU

 Research Assistant
- Dr. LI Bing
 - Dr. LAI Yin-Yan

 Research Technician
 - Ms. Phillis KAU

Patents
8 filed, 2 in process 

Back to top

Collaborations

Current Research Collaborations

Currently 40 research projects in collaboration with colleagues within the University (8+13=21), with other universities in Hong Kong (7), China (8), and overseas (4).

(1) Intra-departmental

  1. Dr. Wutian Wu
    Project:     Neuroprotection and neuroregeneration in spinal cord injury

  2. Prof. Vincent Lee, Honorary Professor
    Project:     Elecetrical stimulation and neuroprotection

  3. Dr.  Raymond Chang
    Project:     Glaucoma and TCM

  4. Dr. Raymond Chang
    Project:     Polysaccharide extract from Lycium barbarum as neuroprotective agent against beta-amyloid peptide neurotoxicity.
    US Provisional Patent filed

  5. Prof. Jen-Fu Chiu
    Project: Proteomic research on glaucoma

  6. Prof. Sookja Chung
    Project: Over-expression of endothelin-1 on diabetic and ischemic retinopathy and glaucoma

  7. Dr. Rutledge Ellis-Behnke
    Project: The use of nanotechnology on axonal regeneration and hemostasis

  8. Dr. Wilson Ching
    Project: Signalling pathways in depression

(2)  Inter-departmental

  1. Dr. Barbara Chan, Medical Engineering, Dept of Electrical & Electronic Engineering
    Project: Photochemically crosslinked collagen scaffolds with enhanced strength and stability.
    US Provisional Patent filed

  2. Dr. Raymond Chang, Anatomy; Prof S.Y. Zee, Botany
    Project:     Lycium barbarum extracts as neuroprotective agents for retinal ganglion cell degeneration
    US Provisional Patent filed

  3. Prof PMG Vanhoutte, Pharmacology; and Prof CM Che, Chemistry
    Project:     Novel application of photosensitive complexes for therapeutic purposes
    US Provisional Patent filed

  4. Prof Tatia Lee, Clinical Psychology
    Project:     Exercise as an antidepressant, its effect on hippocampal neurogenesis in depression

  5. Prof. Tatia Lee, Clinical Psychology, and Prof S.W. Tang, Anatomy
    Project:     Neuroprotection in steroid therapy: an animal model

  6. Dr. Ed Wu, Clinical & Radiology Imaging
    Project:     The structural changes and axonal transport in the optic nerve of glaucoma rats using 7T MRI

  7. Dr. Li-Hai Tan, Faculty of Arts
    Project:     Understanding of brain functions: Chinese reading, visual perception, human learning and development

  8. Dr. Jiangang Shen, School of Chinese Medicine
    Project: Novel pathway for modernization of Chinese Medicine

  9. Prof. Raymond Cheung, Dept of Medicine
    Project:     The effects of self-assembling peptide nanofiber scaffold in a renovascular hypertensive rat model of intracerebral hemorrhage

  10. Prof David Wong, Eye Institute
    Project: The use of SAP in eye surgery

  11. Dr. Amy Lo, Eye Institute
    Project:     The role of hypoxia-inducible factor in eye diseases

  12. Dr. Wico Lai, Eye Institute
    Project: Study on inhibitory agent against proliferative vitreoretinopathy

  13. Dr. Kenneth Li, Eye Institute
    Project:     Safety and efficacy of silicone oil tamponade agents

(3) Local Universities

  1. Dr. Henry Chan, Dept of Optometry & Radiography, HK Polytechnic University
     Project: Changes of inner retinal functions following the induction of ocular hypertension in rat.

  2. Dr. Henry Ho-lung Chan, and Prof To Chi-ho, School of Optometry, HK Polytechnic University
    Project: Retinal signal processing in diseased eyes – New foundation for neuroprotective therapy

  3. Dr. Mason Leung, Dept of Physiotherapy, HK Polytechnic University
    Project: Low level laser and neuroprotection

  4. Dr. Mason Leung, Dept of Physiotherapy, HK Polytechnic University
    Project: The effects of pre-conditioning transcutaneous electrical nerve stimulation (TENS) and treadmill exercise on experimentally induced cerebral ischemia

  5. Dr. Ken Yung, Dept of Biology, HK Baptist University
    Project: Glaucoma NMDA receptor expression

  6. Dr. Qi Cui, Dept of Ophthalmology & Visual Sciences, The Chinese University of HK
    Project: CNTF & RGC protection and axonal regeneration

  7. Prof. Chetwyn Chan, Dept of Rehab. Sciences, HK Polytechnic University
     Dr. Jing Yin, Centre of Buddhist Studies, and Prof Tatia Lee, Clinical Psychology
    Project: Neuroscience and Buddhism

(4) China

  1. Prof. Chen Lin, State Key Laboratory of Brain & Cognitive Sciences, Institute of Biophysics, Beijing
    Project: Brain imaging on dyslexia and normal children

  2. Dr. S.W. You, Institute of Neurosciences, The Fourth Military Medical University, China.
    Project: Optic nerve protection and regeneration

  3. Prof Mingliang PU, Dept of Anatomy & Histo-Embryology, Peking University, China
    Project: neuromechanisms of seasonal affective disorder

  4. Prof Mingliang PU, Dept of Dept of Anatomy & Histo-Embryology, Peking University, China
    Project: Structural and functional study of retinal ganglion cells that are involved in retinal photic signal processing- investigate neuromechanisms of seasonal affective depression

  5. Prof Wang Wei, School of Basic Science, Fujian Medical University, Fuzhou
    Project: Neuroprotection of Jujuboside on the RGC in glaucoma

  6. Prof Luo Xuegang, Dept of Anatomy & Neurobiology, Xiangya School of Medicine, Central South University, Changsha
    Project: NMDA receptor and glaucoma

  7. Dr. Qingling Fu, Otorhinolaryngology Hospital, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou
    Project: Gouqizi and optic nerve injury

  8. Prof Zhang Chun , Clinical Stem Cell Center, Peking University Third Hospital, Beijing
    Project: Cytokines and glaucoma

 (5) International

  1. Prof Gerald Schneider, Dept of Brain and Cognitive Sciences, MIT, USA, and Dr. Rutledge Ellis-Behnke, Dept of Anatomy, HKU
    Project: Roles of self-assembling peptides in regeneration of optic nerve in hamsters, behavioral recovery

  2. Dr. Sha Mi, Molecular Genetics, Biogen Idec Inc., USA; Dr. W. Wu, Dept of Anatomy, HKU
    Project: Regeneration promoting effect of Biogen’s proprietary compounds in optic nerve and spinal cord injurie

  3. Dr. Daniel Lee, GlaxoSmithKline, Neurodegeneration & Translational Medicine, R&D China
    Project: Roles of Nogo receptor fusion protein in retinal ganglion cell survival

  4. Prof Donald K. Ingram, Nutritional Neuroscience and Ageing Laboratory, Louisiana State University System, LA, USA
    Project: Assessing the neuroprotective role of adiponectin in dietary restriction

Back to top

Selected Publications (2005 -    ) 


Source of Impact Factor: 1972-2004: 2003 JCR Science edition, 2005: 2004 JCR Science edition etc.
Citation: from publication to June 2008

As of June 2008, total impact factor is 431.551, and 2,970 citations

  1. (2005) Zhang, C.-W., Lu, Q., You, S.-W., Zhi, Y., Yip, H.K., Wu, W., So, K.-F., and Cui, Q. CNTF and BDNF have similar effects on retinal ganglion cell survival but differential effects on nitric oxide synthase expression soon after optic nerve injury. IOVS Investigative Ophthalmology and Visual Science, 46 (4): 1497-1503. (Ophthalmology: I.F.=4.148, Rank=2/41, top 4.88%, Citation=9).
     

  2. (2005) Chan, H.H., Leung, M. C., and So, K.-F. Electroacupuncture provides a new approach to neuroprotection in rats with induced-glaucoma. J Alternative and Complementary Medicine, Apr. 11(2): 315-322. (I.F.=1.401, Rank=1/1, Citation=7).
     

  3. (2005) Zhi Y., Lu, Q., Zhang, C.W., Yip, H.K., So, K.-F., and Cui, Q.,  Different optic nerve injury sites result in differential responses of retinal ganglion cells to brain-derived neurotrophic factor but not neurotrophin-4/5. Brain Research, 1047: 224-232. (Neurosciences: I.F.=2.389, Rank=91/198, top 46%, Citation=4).
     

  4. (2005) Chan, B.P., and So, K.-F. Photochemical crosslinking improves the physicochemical properties of collagen scaffolds. J. Biomedical Materials Research Part A, Dec 1;75 (3):689-701 (Materials Science, Biomaterials: IF=1.229, Rank=8/15, top 53.3%, Citation=5).
     

  5. (2005) Yu, M.S., Leung, S.K., Lai, S.W., Che, C.M., Zee, S.Y., So, K.-F., Yuen, W.H., and Chang, R.C.C. Neuroprotective effects of anti-aging oriental medicine Lycium barbarum against β-amyloid peptide neurotoxicity. Experimental Gerontology, 40: 716-727. (Geriatrics & Gerontology: I.F.=2.880, Rank’g=7/24, top 24.13%, Citation=10).
     

  6. (2005) Zhang, X.-M., Chen, B.-Y., Ng, A.H.-L., Tanner, J.A., Tay, D., So, K.-F., Rachel, R.A., Copeland, N.G., Jenkins, N.A., and Huang, J.-D. Transgenic mice expressing cre-recombinase specifically in retinal rod bipolar neurons. IOVS Investigative Ophthalmology and Visual Science, Oct., 46 (10): 3515-3520. (Ophthalmology: I.F.=3.577, Rank=2/42, top 4.8%, Citation=1).
     

  7. (2005) Cheung, A.K., Fung M.K., Lo, A.C., Lam, T.T., So, K.-F., Chung, S.S., Chung, S.K. Aldose reductase deficiency prevents diabetes-induced blood retinal barrier breakdown, apoptosis and glial reactivation in the retina of db/db mice. Diabetes Nov; 54 (11) 3119-25 (Endocrinology & Metabolism: I.F.=8.848, Rank’g=4/87, top 4.597%, Citation=18).
     

  8. (2006) Yip, H.K.F., Lai, T.Y.Y., So, K.-F., and Kwok, A.K.H. Retinal ganglion cells toxicity caused by photosensitising effects of intravitreal indocyanine green with illumination in rat eyes. Br.J. Ophthalmol. Jan, 90(1); 99-102. (Ophthalmology: IF=2.000, Rank’g=10/42, top 23.8%, Citation=7).
     

  9. (2006) Yuan, Q., Scott, D.E., So, K.-F., and Wu, W. Developmental changes of nitric oxide synthase expression in the rat hypothalamoneurohypophyseal system. The Anatomical Record Part A. Jan, 288(1): 36-45. (Anatomy & Morphology: IF=1.154, Rank’g=9/16, top 56.25%, Citation=2).
     

  10. (2006) So, K.-F., Ho, L.S.H., Tay, D.K.C., and Lee, T.M.C. Light delays synaptic deafferentation and potentiates the survival of axotomized retinal ganglion cells, Neuroscience Letters, 395: 255-260. (Neurosciences: I.F.=2.019, Rank=113/198, top 57%).
     

  11. (2006) Ellis-Behnke, R.G., Liang, Y.-X., You, S.-W., Tay, D.K.C., Zhang, S., So, K.-F., Schneider, G.E. Nano neuro knitting: peptide nanofiber scaffold for brain repair and axon regeneration with functional return of vision, PNAS (Proceedings of the National Academy of Sciences of the United States of America), March 28, 103 (13): 5054-5059 (I.F.=10.452, Citation=67).
     

  12. (2006) Yu, M.S., Suen, K.C., Kwok, N.S., So, K.-F., Hugon, J., and Chang, R.C.C. Beta-amyloid peptides induces neuronal apoptosis via a mechanism independent of unfolded protein responses., Apoptosis May , 11 (5): 687-700  (Biochemistry & Molecular Biology: I.F.=4.54, Rank’g=  51/261, top 19.5%, Citation=9).
     

  13. (2006) Yuan, Q., Hu, B., So, K.-F., and Wu, W. Age-related re-expression of p75 in axotomized motoneurons. Neuroreport, May 15; 17 (7): 711-5. (Neurosciences: I.F.=2.351, Rank=94/198, top 47%).
     

  14. (2006) Cheng, A.C.O, Yuen, H.K.L., Lucas, P.W., Lam, D.S.C., and So, K.-F. Characterization and localization of the supraorbital and frontal exits of the supraorbital nerve in Chinese: an anatomic study, Ophthalmic Plastic and Reconstructive Surgery, May/ June 22 (3): 209-213. (Ophthalmology: I.F.=0.667, Rank’g=29/42, top 69%, Citation=1).
     

  15. (2006) Yu, M.-S., Ho, Y.-S., So, K.-F., Yuen,W.-H., and Chang, R.C.-C. Cytoprotective effects of Lycium barbarum against reducing stress in endoplasmic reticulum. Int J Molecular Medicine June; 17 (6) 1157-61. (Medicine, Res & Exp: I.F.=3.190, Rank’g=16/40, top 40%, Citation=7).
     

  16. (2006) Li, R.S., Chen, B.-Y., Tay, D.K., Chan, H.H.L., Pu, M.-L., and So, K.-F. Melanopsin-expressing Retinal Ganglion Cells are More Injury-resistant in a Chronic Ocular Hypertension Model. Investigative Ophthalmology and Visual Science (IOVS), 47 (7): 2951-2958 (Ophthalmology: I.F.=3.577, Rank=2/42, top 4.8%, Citation=1).
     

  17. (2006) Chen, B., So, K.-F., Yu, E., and Tay, D.K.C. Expression of nicotinamide adenine dinucleotide phosphate-diaphorase in the retina of postnatal golden hamsters deprived of light stimulation. Neuroscience Letters, 405: 74-78 (Neurosciences: I.F.=2.019, Rank=113/198, top 57%).
     

  18. (2006) Lukehurst, S.S., King, C.E., Beazley, L.D., Tay, D.K.C., So, K.-F., and Rodger, J. Graded ephrin-A2 expression in the developing hamster superior colliculus. Experimental Brain Research, 173: 546-552 (Neurosciences: I.F.=2.304, Rank=99/198, top 50%, Citation=2).
     

  19. (2006) Li, R.S., Tay, D.K., Chan, H.H.L., and So, K.-F. Changes of retinal functions following the induction of ocular hypertension in rats using Argon laser photocoagulation. Clinical and Experimental Ophthalmology, 34: 575-583 (Ophthalmology: I.F.=1.031, Rank=23/42, top 54.8%, Citation=1).
     

  20. (2006) Ellis-Behnke, R., So, K.-F., and Zhang, S. Molecular repair of the brain using self-assembling peptides Chemistry Today 24 (4): 42-43.
     

  21. (2006) Pu, M., Chen, B., Li, R.S., Tay, D., and So, K.-F. A suprachiasmatic nucleus projecting retinal ganglion cell exhibits an unusually large dendritic field in the hamster. Neuroreport, Oct 2; 17(14):1469-1472 (Neurosciences: I.F.=2.351, Rank’g=94/198, top 47%).
     

  22. (2006) Yuan, Q., Scott, D.E., Wu, W., and So, K.F. The response of magnocellular neurons of the hypothalamo-neurohyphyseal system to hypophysectomy, nitric oxide synthase expression as well as survival and regeneration in developing versus adult rats. Brain Research, 1113: 45-53 (Neurosciences: I.F.=2.389, Rank’g=91/198, top 46%, Citation=1).
     

  23. (2006) Ellis-Behnke, R.G., Liang, Y.-X., Tay, D.K.C., Kau, P.W.F., Schneider, G.E., Zhang, S., Wu, W., and So, K.-F. Nano hemostat solution: immediate hemostasis at the nanoscale. Nanomedicine: Dec;2(4):207-15. [Epub 2006 Oct 12].
     

  24. (2006)  Ji, B., Li, M., Wu, W.-T., Yick, L.-W., Lee, X., Shao, Z., Wang, J., So, K.-F., McCoy, J.M., Pepinsky, R.B., Mi. S., and Relton, J.K. LINGO-1 antagonist promotes functional recovery and axonal sprouting after spinal cord injury, Molecular and Cellular Neuroscience, Nov, 33 (3): 311-320 (Neurosciences: I.F.=4.641, Rank’g=27/200, top 13.5%, Citation=9).
     

  25. (2006) Schneider, G., Ellis-Behnke, R., Liang, Y.X., Kau, P.W.F., Tay, D.K.C., and So, K.-F. Behavioral testing and preliminary analysis of the hamster visual system. Nature Protocols, 1(4): 1898-1905.
     

  26. (2007) Chan, H.-C., Chang, R.C.C., Ip, A.K.-C., Chiu, K., Yuen, W.-H., Zee, Y.-Z., and So, K.-F. Neuroprotective effects of Lycium barbarum Lynn on protecting retinal ganglion cells in an ocular hypertension model of glaucoma. Experimental Neurology 203: 269-273. [Epub ahead of print Oct 11, 2006] (Neurosciences: I.F.=3.369, Rank’g=53/198, Top 27%, Citation=5).
     

  27. (2007) Chan, B.P., Hui, T.Y., Chan, O.C., So, K.-F., Lu, W., Cheung, K.M., Salomatina, E., and Yaroslavsky, A. Photochemical cross-linking for collagen-based scaffolds: a study on optical properties, mechanical properties, stability and hematocompatibility. Tissue Engineering Jan;13 (1):73-85 (I.F.=3.143, Citation=3) , [Nov 1 2006, Epub ahead of print].
     

  28. (2007) Tang, E.H.C., Leung, F.P., Huang, Y., Feletou, M., So, K.-F., Man, R.Y.K., and Vanhoutte, P.M. Calcium and reactive oxygen species increase in endothelial cells in response to releasers of endothelium-derived contracting factor. British J Pharmacology May (2007), 151:15 - 23 (Pharmacology & Pharmacy, I.F.: 3.410, Rank’g: 42/193, top 22%, Citation=6).
     

  29. (2007) Lau, B.W., Qiu, G., Helmested, D.M., Lee, T.M.C., Tang, S.W., and So, K.-F.,  Corticosteroid decreases subventricular zone cell proliferation, which could be reversed by paroxetine. Restor Neurol Neurosci. (Neurosciences: I.F.=2.862, Rank’g:80/199, top 40%),  25(1):17-23.
     

  30. (2007) Yu, M.-S., Wong, A.Y.-Y., So, K.-F., Fang, J.-N., Yuen, W.-H., and Chang, R.C.-C., New polysaccharide from Nerium indicum protects neurons via stress kinase signaling pathway. Brain Res. 1153: 221-230 (Neurosciences: I.F.=2.341, Rank’g:106/199, top 53%, Citation=1), [Epub ahead of print Mar 30].
     

  31. (2007) Qiu, G., Helmeste, D.M., Samaranayake, A.N., Lau, W.-M., Lee, T.M.C., Siu-Wa Tang, and So K.-F., Modulation of the suppressive effect of corticosterone on adult rat hippocampal cell proliferation by paroxetine. Neuroscience Bulletin, 23 (3): 131-136.
     

  32. (2007) Ho, Y.S., Yu, M.S., Lai, C.S., So, K.-F., Yuen, W.H., and Chang, R.C., Characterizing the neuroprotective effects of alkaline extract of Lycium barbarum on beta-amyloid peptide neurotoxicity. Brain Res July 16, 1158:123-34 (Neurosciences: I.F.=2.341, Rank’g:106/199, top 53%, Citation=1), [2007 May 6 Epub ahead of print].
     

  33. (2007) Yuan, Q., Scott, D.E., So, K.-F, and Wu, W., A subpopulation of reactive astrocytes at affected neuronal perikarya after hypophysectomy in adult rats. Brain Res. 1159: 18-27 (Neurosciences: I.F.=2.341, Rank’g:106/199, top 53%), [2007 May 26; Epub ahead of print].
     

  34. (2007) Ellis-Behnke, R.G., Teather, L.A., Schneider, G.E., and So, K.-F., Using nanotechnology to design potential therapies for CNS regeneration. Current Pharmaceutical Design, 13: 2519-2528 (Pharmacology & Pharmacy, I.F.: 5.270, Rank’g: 17/199, top 9%, Citation=1).
     

  35. (2007) Cen, L.-P., Luo, J.-M., Zhang, C.-W., Fan, Y.-M., Song, Y.,So, K.-F., van Rooijen, N., Pang, C.P., Lam, D.S.C., and Cui, Q., Chemotactic effect of ciliary neurotrophic factor on macrophages in Retinal Ganglion Cell Survival and Axonal Repair. IOVS, Sept (48) 9: 4257-4266. (Ophthalmology, I.F.: 3.766, Rank’g: 3/45, top 7%, Citation=5).
     

  36. (2007) Yuan Q., Scott, D.E., So, K.-F., and Wu, W., Differential Activation of c-fos immunoreactivity after hypophysectomy in developing and adult rats. The Anatomical Record, 290: 1050-1056 (Anatomy & Morphology, I.F.: 1.973, Rank’g: 3/15, top 20%).
     

  37. (2007) Lau, B.W.M., Tsao, G.S.W., So, K.-F., and Yip, H.K., Expression of telomerase reverse transcriptase in adult goldfish retina. J. Molecular Neuroscience, 32: 160 - 167 (Neurosciences: I.F.=2.965, Rank’g:74/200, top 37%).
     

  38. (2007) Cheung, A.K.H., Lo, A.C.Y., So, K.-F., Chung, S.S.M., and Chung, S.K., Gene deletion and pharmacological inhibition of aldose reductase protect against retinal ischemic injury. Experimental Eye Res,85: 608-616 [Epub ahead of print, Jul 25] (Ophthalmology: IF=2.776, Rank’g: 7/45, top 16%).
     

  39. (2007) Yu, M.-S., Lai, C.S., Ho, Y.-S., Zee, S.-Y., So, K.-F., Yuen, W.-H., and Chang, R.C.-C., Characterization of the effects of anti-aging medicine Fructus lycii on ß-amyloid peptide neurotoxicity. Int’ J Molecular Medicine, Aug; 20(2):261-8 (Medicine, Research and Experimental: I.F.=1.854, Rank’g:34/76, top 45%, Citation=1).
     

  40. (2007) Shi, Y., So, K.-F., Man, R.Y.K., and Vanhoutte, P.M., Oxygen-derived free radicals medicate endothelium-dependent contractions in femoral arteries or rats with streptozotocin-induced diabetes. British J Pharmacology [Epub ahead of print, Sept 3], Dec; 152(7): 1033-41 (Pharmacology & Pharmacy, I.F.: 3.410, Rank’g: 42/193, top 22%, Citation=3).
     

  41. (2007) Mi, S., Hu, B., Hahm, K., Luo, Y., Hui, E.S.K., Yuan, Q., Wong, W.M., Wang, L., Su, H., Chu, T.-H., Guo, J., Zhang, W., So, K.-F., Pepinsky, B., Shao, Z., Graff, C., Garber, E., Jung, V., Wu, E.X., and Wu, W., LINGO-1 antagonist promotes spinal cord remyelination and axonal integrity in MOG-induced experimental autoimmune encephalomyelitis. Nature Medicine, Oct, 13 (10): 1228-33. [Epub 2007 Sept 30] (Medicine, Research & Experimental: I.F.=28.588, Rank’g: 1/76, top %, Citation=5).
     

  42. (2007) Mi, S., Hu, B., Hahm, K., Luo, Y., Hui, S.K., Yuan, Q., Wong W.M., Wang, L., Su, H.X., Chu, T.H., Guo, J.S., Zhang, W.M., So, K.-F., Pepinsky, B., Shao, Z.H., Graff, C., Garber, E., Jung, V., Wu, X.K., and Wu, W., Rodent EAE model for the study of axon integrity and remyelination. Nature Protocols, DOI: 10. 1038/ nprot. 2007. 389.
     

  43. (2007) Guo, J., Su, H., Zeng, Y., Liang, Y.X., Wong, W.M., Ellis-Behnke, R.G., So, K.-F., and Wu, W., Reknitting the injured spinal cord by self-assembling peptide nanofiber scaffold. Nanomedicine, Dec; 3(4): 311-21 [Epub ahead of print 2007 Oct 26].
     

  44. (2007) Chiu, K., Lau W.M., Lau, H.T., So, K.-F., Chang, R.C.C., Micro-dissection of rat brain for RNA or protein extraction from specific brain region. J Visualized Experiments. 7.

     http://www.jove.com/index/Details.stp?ID=269, doi:10.3791/269

  45. (2007) Chiu K., Chang, R.C.C., So, K.-F., Intravitreous injection for establishing ocular diseases model. J Visualized Experiments. 8. http:///www.jove.com/index/Details.stp?ID=313, doi:10.3791/313.
     

  46. (2007) Chiu, K., Chang, R., So, K.-F., Laser-induced Chronic Ocular Hypertension Model on SD Rats. J Visualized Experiments. 10. http://www.jove.com/index/Details.stp?ID=549, doi:10.3791/1549
     

  47. (2008) Chiu, K., Lau, W.M., Yeung, S.C., Chang, R.C.C., So, K.-F., Retrograde labeling of retinal ganglion cells by application of Fluoro-Gold on the surface fo superior colliculus. J Visualized Experiments. 16. http://www.jove.com/index/Details.stp?ID=819, doi: 10.3791/819.
     

  48. (2008) Chang, R.C.C., and So, K.-F., Use of anti-aging herbal medicine, Lycium barbarum, against aging-associated diseases. What do we know so far?" Cellular and Molecular Neurobiology, [Epub ahead of print, Aug 21, 2007] 28: 643-652 (Neurosciences: I.F.=2.219, Rank’g:114/200, top 57%).
     

  49. (2008) Cheung, Z.H., Leung, M.C.P., Yip, H.K., Wu, W., Siu, F.K.W., and So, K.-F., A Neuroprotective Herbal Mixture Inhibits Caspase-3-independent Apoptosis in Retinal Ganglion Cells. Cellular and Molecular Neurobiology, 28: 137-155 [Epub ahead of print, Aug 21], (Neurosciences: I.F.=2.219, Rank’g:114/200, top 57%).
     

  50. (2008) Fu, Q.L., Wu, W., Wang, H., Li, X., Lee, V.W., and So K.-F., Up-regulated Endogenous Erythropoietin/Erythropoietin Receptor System and Exogenous Erythropoietin Rescue Retinal Ganglion Cells after Chronic Ocular Hypertension. Cell Mol Neurobiol. 28:317-329, [2007 Jun 7, Epub ahead of print] (Neurosciences: I.F.=2.219, Rank’g:114/200, top 57%).
     

  51. (2008) Lau, B.W., Wong, A.O., Tsao, G.S., So, K.-F., Yip, H.K., Molecular Cloning and Characterization of the Zebrafish (danio rerio) Telomerase Catalytic Subunit (Telomerase Reverse Transcriptase, TERT). J. Mol. Neurosci., 34 (1): 63-75 [Epub 2007 Sept 19] (Neurosciences: I.F.=2.965, Rank’g: 74/200, top37%).
     

  52. (2008) Chan, K.C., Fu, Q.-L., Hui, E.S., So, K.-F., and Wu,E.X., Evaluation of the Retina and Optic Nerve in a Rat Model of Chronic Glaucoma using in vivo Manganese-enhanced Magnetic Resonance Imaging. NeuroImage, Apr 40(3): 1166-1174 [Epub ahead of print Jan 17] (Neurosciences: I.F.=5.559, Rank’g: 23/200, top 12%).
     

  53. (2008) Lai, C.S., Yu, M.S., Yuen, W.H., So, K.-F., Zee, S.Y., Chang, R.C., Antagonizing beta-amyloid peptide neurotoxicity of the anti-aging fungus Ganoderma Lucidum. Brain Res.1190: 215-224, 23 Jan 2008 [Epub ahead of print Nov 13, 2007], (Neurosciences: I.F.-2.341, Rank’g: 107/200, top 54%).
     

  54. (2008) Fu,Q.-L., Hu, B., Wu, W., Pepinsky, R.B., Mi,S., and So, K.-F., Blocking LINGO-1 function promotes retinal ganglion cell survival following ocular hypertension and optic nerve transaction. IOVS, 49: 975-985 (Ophthalmology: I.F.=3.766, Rank’g: 3/45, top 7%).
     

  55. (2008) Cheng, A.C.O., Lucas, P.W., Yuen, H.K.L., Lam, D.S.C., and So, K.-F., Surgical anatomy of the Chinese orbit. Ophthalmic Plastic and Reconstructive Surgery, 24(2): 136-141 (Ophthalmology: I.F.=0.893, Rank’g: 32/40, top 80%; Surgery: I.F.=0.893, Rank’g: 89/137, top 65%).
     

  56. (2008) Chan, O.C.M., So, K.-F., and Chan, B.P., Fabrication of nano-fibrous collagen microspheres for protein delivery and effects of photochemical crosslinking on release kinetics. J Controlled Release [Epub ahead of print, Apr 22], 129(2):135-43 (Chemistry, Multidisciplinary: I.F.=4.012, Rank’g: 16/124, top 13%).
     

  57. (2008) Li, S.-Y., Yau, S.-Y., Chen, B.-Y., Tay, D.K., Lee, V.W.H., Pu, M.-L., Chan, H.H.L., and So, K.-F., Enhanced Survival of Melanopsin-expressing Retinal Ganglion Cells After Injury is Associated with the PI3 K/Akt Pathway. Cell Mol. Neurobiol., [Epub ahead of print May 30] (Neurosciences: I.F.=2.219, Rank’g:114/200, top 57%).
     

  58. (2008) Chan, BP, Chan, O.C.M., and So, K.-F., Effects of photochemical crosslinking on the microstructure of collagen and a feasibility study on controlled protein release, Acta Biomaterialia [Epub ahead of print, Jul 1] , (Materials Science, Biomaterials: I.F.=3.113, Rank’g: 2/16, top 13%).
     

  59. (2008) Chan, K.C., Fu, Q.-L., Guo, H., So, K.-F., Wu, E.X., Gd-DTPA Enhanced MRI of Ocular Transport in a Rat Model of Chronic Glaucoma, Experimental Eye Res, [Epub ahead of print, Jun 28] (Ophthalmology: I.F.=2.651, Rank’g: 9/45, top 20%).

Back to top

 
Copyright © 2006 The University of Hong Kong