The Deparment has various research interests and teams of open-minded researchers that are dedicated to exploring them. Utilizing a post-genomic approach, we are able to study cell biology and signaling, investigate novel therapeutic interventions of diseases, for example, the use of Chinese medicinal herbs. There is also active collaboration between clinicians and scientists in the Department.
Research Methodology
- Morphology and image analysis
- Confocal microscopy, laser capture, microdissection
- Molecular biology (cDNA arrays, QPCR, proteomics)
- Cell Biology (cell cultures, cell line establishment, transfection, cytogenetics)
- Cell signaling
- Functional morphology and field studies
- Animal models for human diseases
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Overview of the Deparment's research areas |
Technical Facilities
Research Labs
Bioinformatics Lab
Cancer Biology Lab
Cell & Reproductive Biology Lab
Neuroscience Lab
Proteonomic Lab
Sensory Science & Cell Biology Lab |
Core Facilities
Animal Surgery Room
Audiovisual Room
Cold Room
Computer Room
Culture Lab
Dark Room
EM Preparation Lab
Histology Lab
Imaging Lab
Microscope & Morphometry Room
Radioisotope Lab
Workshop |
Core Equipment
Confocal Microscope
Flow Cytometer
Laser Capture
Microdissection System
Real-time PCR |
Research Highlights from
the Department
Prof. Kwok-Fai So /
Dr. David Tay / Dr. Henry
Yip / Dr. Wutian Wu /
Dr. Raymond CC Chang /
Dr. Wai-Sum O / Dr. George Tipoe
Neuroprotection and Axonal
Regeneration of Retinal Ganglion Cells
Prof. Kwok-Fai So
- Molecular signaling of
cell death and neuroprotection in a rat glaucoma model
- Use of agents (eg.
trophic factors, LiCl, TCM etc) to promote survival and
axonal regeneration of retinal ganglion cells
- Investigate potential
immune mechanisms involved in mediating neuroprotective
effect of TCM
Neurotrophic factors affects axonal
regeneration of injured retinocollicular projections
Dr. David Tay
Neural Development and Protection
Dr. Henry Yip
- Trk receptor signaling
is required for establishment of compartmentalization in
the cerebellum
- Telomerase in CNS
repair
- Synergistic effects of
Neurotrophic factors and Cytokines in ischemic retina
- Herbal extracts
protects Dopaminergic neurons against MPTP-toxicity
Degeneration of Adult Motoneurons:
Mechanisms and Prevention
Dr. Wutian Wu
- Gene expression changes
in adult spinal motoneurons following axonal injury.
- Intracellular molecular
pathways responsible for motoneuron death after axonal
injury.
- Role of nitric oxide
synthase on motoneurons degeneration and regeneration
after spinal root avulsion.
- New therapeutic
approaches to prevent the death of motoneurons due to
root avulsion and enhance the survival and regeneration
after axonal injury.
Molecular Signaling of Degeneration
Dr. Raymond CC Chang
- Role of cell stress
kinases in neuronal death (PKR, PERK, p38 & JNK)
- Implication of cellular
ER and Golgi in neuronal apoptosis
- Molecular signaling and
therapeutic targets in Alzheimer’s disease
- Role of neuro-inflammation
in neurodegeneration
Biology of Reproduction
Dr. Wai-Sum O
Physiological functions
of male accessory sex glands in fertilization,
implantation and early embryonic development
Maturation of oocytes in vitro: benchmarking and
implication for infertility
Lung and Liver Injury
Dr. George Tipoe
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